Clinical trialNCT00109850TerminatedPhase 2Interventional

S0414 Cetuximab, Combo Chemo, and RT in Locally Advanced Esophageal Cancer

SponsorSWOG Cancer Research NetworkEnrollment22Esophageal Cancer

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

RATIONALE: Monoclonal antibodies, such as cetuximab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. Cetuximab may also stop the growth of esophageal cancer by blocking blood flow to the tumor and by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as cisplatin and irinotecan, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Radiation therapy uses high-energy x-rays to kill tumor cells. Giving cetuximab together with combination chemotherapy and radiation therapy may kill more tumor cells. PURPOSE: This phase II trial is studying how well giving cetuximab together with combination chemotherapy and radiation therapy works in treating patients with locally advanced esophageal cancer that cannot be removed by surgery.

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Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Charles D. Blanke, MD, FACP
OHSU Knight Cancer Institute
Study ChairKOL profile →
clinicaltrials.gov ↗
Charles R. Thomas, MD
OHSU Knight Cancer Institute
Study Chair
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James L. Abbruzzese, MD
M.D. Anderson Cancer Center
Study Chair
clinicaltrials.gov ↗
Lisa Hammond, MD
The University of Texas Health Science Center at San Antonio
Study Chair
clinicaltrials.gov ↗
Vivek Mehta, MD
Swedish Cancer Institute at Swedish Medical Center - First Hill Campus
Study Chair
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

132 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Mobile Infirmary Medical Center
Mobile, Alabama, United States
Arkansas Cancer Research Center at University of Arkansas for Medical Sciences
Little Rock, Arkansas, United States
Alta Bates Comprehensive Cancer Center
Berkeley, California, United States
Providence Saint Joseph Medical Center - Burbank
Burbank, California, United States
Peninsula Medical Center
Burlingame, California, United States
Eden Medical Center
Castro Valley, California, United States
Marin Cancer Institute at Marin General Hospital
Greenbrae, California, United States
Sutter Health - Western Division Cancer Research Group
Greenbrae, California, United States
Saint Rose Hospital
Hayward, California, United States
Usc/norris Comprehensive Cancer Center and Hospital
Los Angeles, California, United States
Alta Bates Summit Medical Center - Summit Campus
Oakland, California, United States
Ccop - Bay Area Tumor Institute
Oakland, California, United States
Highland General Hospital
Oakland, California, United States
Desert Regional Medical Center Comprehensive Cancer Center
Palm Springs, California, United States
Valley Care Medical Center
Pleasanton, California, United States
University of California Davis Cancer Center
Sacramento, California, United States
California Pacific Medical Center - California Campus
San Francisco, California, United States
Doctors Medical Center - San Pablo Campus
San Pablo, California, United States
Ccop - Santa Rosa Memorial Hospital
Sana Rosa, California, United States
Sutter Solano Medical Center
Vallejo, California, United States
Poudre Valley Hospital
Fort Collins, Colorado, United States
Watson Clinic, Llc
Lakeland, Florida, United States
Augusta Oncology Associates - Walton Way
Augusta, Georgia, United States
Curtis & Elizabeth Anderson Cancer Institute at Memorial Health University Medical Center
Savannah, Georgia, United States
Nancy N. and J. C. Lewis Cancer and Research Pavilion at St. Joseph'S/candler
Savannah, Georgia, United States
St. Luke'S Mountain States Tumor Institute - Boise
Boise, Idaho, United States
Regional Cancer Center at Memorial Medical Center
Springfield, Illinois, United States
St. Francis Hospital and Health Centers - Beech Grove Campus
Beech Grove, Indiana, United States
Reid Hospital & Health Care Services, Incorporated
Richmond, Indiana, United States
Cancer Center of Kansas, Pa - Chanute
Chanute, Kansas, United States
Cancer Center of Kansas, Pa - Dodge City
Dodge City, Kansas, United States
Cancer Center of Kansas, Pa - El Dorado
El Dorado, Kansas, United States
Kansas Masonic Cancer Research Institute at the University of Kansas Medical Center
Kansas City, Kansas, United States
Cancer Center of Kansas, Pa - Kingman
Kingman, Kansas, United States
Southwest Medical Center
Liberal, Kansas, United States
Cancer Center of Kansas, Pa - Newton
Newton, Kansas, United States
Cancer Center of Kansas, Pa - Parsons
Parsons, Kansas, United States
Cancer Center of Kansas, Pa - Pratt
Pratt, Kansas, United States
Cancer Center of Kansas, Pa - Salina
Salina, Kansas, United States
Tammy Walker Cancer Center at Salina Regional Health Center
Salina, Kansas, United States

92 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Cetuximab →Cisplatin →Irinotecan →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 31 May 2005
Primary completion: 30 Sept 2009
Completion: 31 May 2012
Last update posted: 18 Nov 2015
Registered enrollment: 22
Registry id: NCT00109850

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.