Clinical trialNCT00127205CompletedPhase 3Interventional

S0307 Phase III Trial of Bisphosphonates as Adjuvant Therapy for Primary Breast Cancer.

SponsorSWOG Cancer Research NetworkEnrollment6,097Breast Cancer

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

RATIONALE: Zoledronate, clodronate, or ibandronate may delay or prevent bone metastases in patients with nonmetastatic breast cancer. It is not yet known whether zoledronate is more effective than clodronate or ibandronate in treating breast cancer. PURPOSE: This randomized phase III trial is studying zoledronate to see how well it works compared to clodronate or ibandronate in treating women who have undergone surgery for stage I, stage II, or stage III breast cancer.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

Alexander H Paterson, MD, FRCP
Tom Baker Cancer Centre - Calgary
Study Chair
clinicaltrials.gov ↗
Carla I. Falkson, MD
University of Alabama at Birmingham
Study Chair
clinicaltrials.gov ↗
Elizabeth C. Dees, MD
UNC Lineberger Comprehensive Cancer Center
Study Chair
clinicaltrials.gov ↗
James N. Ingle, MD
Mayo Clinic
Study Chair
clinicaltrials.gov ↗
Julie R. Gralow, MD
Seattle Cancer Care Alliance
Study Chair
clinicaltrials.gov ↗
Mark J. Clemons, MD
Toronto Sunnybrook Regional Cancer Centre
Study Chair
clinicaltrials.gov ↗
Robert B. Livingston, MD
University of Arizona
Study Chair
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

No facility list is in our current data snapshot for this study. The registry record on ClinicalTrials.gov ↗ carries any published locations. Why? →

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Clodronic acidIbandronate →Zoledronic acid →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 31 Jul 2005
Primary completion: 31 Dec 2017
Completion: 29 Mar 2021
Last update posted: 2 Jul 2021
Registered enrollment: 6,097
Registry id: NCT00127205

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 4 Nov 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.