Clinical trialNCT00144430CompletedPhase 2Interventional

Pentostatin for High Risk and Refractory Chronic Graft Versus Host Disease in Children

SponsorAnn & Robert H Lurie Children's Hospital of ChicagoEnrollment60Graft vs Host Disease

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This is a multicenter trial through the Pediatric Blood and Marrow Transplant Consortium. The Primary hypothesis of this study is that because of its effect as a potent immunosuppressive agent targeting lymphocytes, pentostatin will show a sustained response in pediatric subjects with severe chronic GVHD. Secondary hypotheses include that the infection and toxicity rate of pentostatin in this setting will be acceptable given its lack of severe myelosuppression, and subjects with refractory chronic GVHD will have significant QOL impairment and symptomatology. These may change as subjects are being treated for their chronic GVHD with pentostatin.

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Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

David Jacobsohn, MD, MSc
Children's Memorial Hospital, Chicago, IL
Principal Investigator
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A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

25 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Loma Linda University Medical Center
Loma Linda, California, United States
Pediatric Medical Center for Northern California
Oakland, California, United States
Nemour'S Children'S Clinic
Jacksonville, Florida, United States
University of Miami
Miami, Florida, United States
All Children'S Health System
St. Petersburg, Florida, United States
Children'S Healthcare of Atlanta
Atlanta, Georgia, United States
Children'S Memorial Hospital
Chicago, Illinois, United States
Riley Hospital for Children
Indianapolis, Indiana, United States
Lsuhsc
New Orleans, Louisiana, United States
John'S Hopkins
Baltimore, Maryland, United States
University of Michigan
Ann Arbor, Michigan, United States
Devos Children'S Hospital
Grand Rapids, Michigan, United States
Children'S Mercy Hospital
Kansas City, Missouri, United States
St. Louis University
St Louis, Missouri, United States
Hackensack University Medical Center
Hackensack, New Jersey, United States
Columbia Presbyterian Medical Center
New York, New York, United States
New York Medical College
Valhalla, New York, United States
Rainbow Babies and Children'S
Cleveland, Ohio, United States
Columbus Children'S Hospital
Columbus, Ohio, United States
Penn State Milton S. Hershey Medical Center
Hershey, Pennsylvania, United States
Children'S Hospital of Philadelphia
Philadelphia, Pennsylvania, United States
Victor Aquino, Md
Dallas, Texas, United States
Cook Children'S Medical Center
Fort Worth, Texas, United States
Southwest Texas Methodist Hospital
San Antonio, Texas, United States
University of Utah
Salt Lake City, Utah, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Pentostatin

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 31 Jan 2004
Primary completion: 31 Aug 2008
Completion: 31 Aug 2008
Last update posted: 3 Feb 2009
Registered enrollment: 60
Registry id: NCT00144430

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.