Clinical trialNCT00164255CompletedPhase 4Interventional

Efficacy of Combination Therapy for Prevention of Effects of Malaria During Pregnancy

SponsorCenters for Disease Control and PreventionEnrollment1,614Malaria

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This study is an investigation to compare the efficacy of two different intermittent sulfadoxine/pyrimethamine (SP) treatment regimens and intermittent sulfadoxine/pyrimethamine (SP) + artesunate (SP/AS) treatment of HIV negative and positive mothers in clearing placental parasitemia at delivery. If intermittent protective SP/AS treatment is equally efficacious and safe as intermittent protective SP, such a regimen could be adapted for programmatic use as a potentially more durable alternative to SP monotherapy in areas of increasing SP resistance.

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Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

John MacArthur, MD, MPH
Centers for Disease Control and Prevention
Principal Investigator
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Salim Abdulla, MD, PhD
Ifakara Health Research and Development Centre
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

2 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Tanzania

Kibaoni Health Centre
Ifakara, Kilombero District, Tanzania
St Francis Designated District Hospital
Ifakara, Kilombero District, Tanzania

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Sulfadoxine

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 31 Jan 2003
Primary completion: 30 Jun 2009
Completion: 30 Jun 2009
Last update posted: 11 Sept 2012
Registered enrollment: 1,614
Registry id: NCT00164255

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.