Clinical trialNCT00212472TerminatedInterventional

International Immune Tolerance Study

SponsorNew York Presbyterian HospitalEnrollment134Hemophilia A With Inhibitors

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The purpose of this study is to see if a low-dose arm or a high dose-arm of immune tolerance is more effective in eliminating inhibitors in patients with hemophilia A.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Charles Hay, MD
Manchester Royal Infirmary
Principal Investigator
clinicaltrials.gov ↗
Donna M DiMichele, MD
Weill Cornell Medical College-NY Presybetrian Hospital
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

39 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

University of Alabama Birmingham Medical Center
Birmingham, Alabama, United States
City of Hope Medical Center
Duarte, California, United States
Children'S Hospital of Orange County
Orange, California, United States
Mountain States Regional Hemophilia and Thrombosis Center
Aurora, Colorado, United States
All Children'S Hospital
St. Petersburg, Florida, United States
Children'S Healthcare of Atlanta
Atlanta, Georgia, United States
Children'S Memorial Hospital
Chicago, Illinois, United States
Rush Presbyterian St. Lukes
Chicago, Illinois, United States
Comprehensive Bleeding Disorders Center
Peoria, Illinois, United States
Indiana Hemophilia & Thrombosis Center
Indianapolis, Indiana, United States
Tulane University Hospital and Clinic
New Orleans, Louisiana, United States
Maine Children'S Cancer Program
Scarborough, Maine, United States
Children'S Hospital Boston
Boston, Massachusetts, United States
Tufts - New England Medical Center
Boston, Massachusetts, United States
University of Michigan Health Hospitals
Ann Arbor, Michigan, United States
Msu Centers for Bleeding & Clotting Disorders
East Lansing, Michigan, United States
Children'S Hospital Minneapolis
Minneapolis, Minnesota, United States
Mayo Comprehensive Hemophilia Center
Rochester, Minnesota, United States
Kansas City Regional Hemophilia Center-the Children'S Mercy Hospital
Kansas City, Missouri, United States
Hackensack University Medical Center
Hackensack, New Jersey, United States
Newark Beth Israel Medical Center
Newark, New Jersey, United States
Saint Michael'S Medical Center
Newark, New Jersey, United States
Ted R. Montoya Hemophilia Treatment Center
Albuquerque, New Mexico, United States
Mount Sinai Medical Center
New York, New York, United States
Ny Presbyterian Hospital
New York, New York, United States
University of North Carolina at Chapel Hill
Chapel Hill, North Carolina, United States
Children'S Hospital Medical Center of Akron
Akron, Ohio, United States
Cincinnati Children'S Hospital Medical Center
Cincinnati, Ohio, United States
Columbus Children'S Hospital
Columbus, Ohio, United States
Oregon Health and Science University
Portland, Oregon, United States
Children'S Hospital of Philadelphia
Philadelphia, Pennsylvania, United States
St. Christopher'S Hospital for Children, Section of Hem/onc
Philadelphia, Pennsylvania, United States
the Hemophilia Center of Western Pennsylvania
Pittsburgh, Pennsylvania, United States
St. Jude Children'S Research Hospital
Memphis, Tennessee, United States
Vanderbilt University Medical Center
Nashville, Tennessee, United States
University of Texas Health Science Center-Gulf States Hemophilia & Thrombosis Center
Houston, Texas, United States
Children'S Hospital of the King'S Daughters
Norfolk, Virginia, United States
Naval Medical Center
Portsmouth, Virginia, United States
Comprehensive Center for Bleeding Disorders
Milwaukee, Wisconsin, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Factor VIII concentrates

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 31 Jul 2002
Primary completion: 31 Dec 2010
Completion: 31 Dec 2012
Last update posted: 7 Dec 2009
Registered enrollment: 134
Registry id: NCT00212472

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.