findmyKOL
Clinical trialNCT00235716CompletedPhase 3Interventional

A Randomized, Clinical Trial of Vitamin E and Memantine in Alzheimer's Disease

SponsorUS Department of Veterans AffairsEnrollment613Alzheimer's Disease
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The purpose of this study is to determine whether alpha-tocopherol, memantine (Namenda), or the combination will significantly delay clinical progression in mild to moderately demented patients with Alzheimer's disease compared to placebo.

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

14 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Puerto Rico
  • Va Medical Center, San Juan

    San Juan, Puerto Rico

United States
  • Va Medical Center, Bay Pines

    Bay Pines, Florida, United States

  • Va Medical Center, Miami

    Miami, Florida, United States

  • Va Medical Center, Iowa City

    Iowa City, Iowa, United States

  • Va Maryland Health Care System, Baltimore

    Baltimore, Maryland, United States

  • Va Medical Center, Jamaica Plain Campus

    Boston, Massachusetts, United States

  • Va Ann Arbor Healthcare System

    Ann Arbor, Michigan, United States

  • Va Medical Center, Minneapolis

    Minneapolis, Minnesota, United States

  • Salisbury Vamc

    Salisbury, North Carolina, United States

  • Va Medical Center, Cleveland

    Cleveland, Ohio, United States

  • Ralph H Johnson Va Medical Center, Charleston

    Charleston, South Carolina, United States

  • Va North Texas Health Care System, Dallas

    Dallas, Texas, United States

  • Va Puget Sound Health Care System, Seattle

    Seattle, Washington, United States

  • Wlliam S. Middleton Memorial Veterans Hospital, Madison

    Madison, Wisconsin, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Memantine →PlaceboVitamin E
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
31 Aug 2007
Primary completion
30 Sept 2012
Completion
31 Oct 2012
Last update posted
23 Jul 2014
Registered enrollment
613
Registry id
NCT00235716

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.