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Clinical trialNCT00245336CompletedPhase 3Interventional

Study of Recombinant Human Thrombin for Bleeding During Surgery

SponsorZymoGeneticsEnrollment401Surgical Hemostasis
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The purpose of this study is to determine whether recombinant human Thrombin (rhThrombin) is effective in stopping bleeding during surgery, in comparison with bovine thrombin.

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

29 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States
  • Cardio Thoracic Surgeons, P.C.

    Birmingham, Alabama, United States

  • Cardio Thoracic Surgeons, P.C., Medical Center East / Baptist Montclair

    Birmingham, Alabama, United States

  • University of Alabama at Birmingham

    Birmingham, Alabama, United States

  • Methodist Hospital

    Arcadia, California, United States

  • Glendale Adventist Medical Center

    Glendale, California, United States

  • University of Southern California, Keck School of Medicine

    Los Angeles, California, United States

  • University of Southern California, Keck School of Medicine

    Los Angeles, California, United States

  • Huntington Memorial Hospital

    Pasadena, California, United States

  • Baptist Clinical Research

    Pensacola, Florida, United States

  • H. Lee Moffitt Cancer Center and Research Institute

    Tampa, Florida, United States

  • Northwestern Memorial Hospital

    Chicago, Illinois, United States

  • Northwestern University Vascular Surgery

    Chicago, Illinois, United States

  • Indiana Spine Group

    Indianapolis, Indiana, United States

  • Bluegrass Orthopedics/bluegrass Musculoskeletal Research

    Lexington, Kentucky, United States

  • Vascular Surgery Associates

    Baton Rouge, Louisiana, United States

  • Tulane University Abdominal Transplant

    New Orleans, Louisiana, United States

  • Vamc Clinical Research Center

    Detroit, Michigan, United States

  • Washington University School of Medicine

    St Louis, Missouri, United States

  • Mt. Sinai School of Medicine

    New York, New York, United States

  • Duke University Medical Center

    Durham, North Carolina, United States

  • University of Pittsburgh Medical Center

    Pittsburgh, Pennsylvania, United States

  • Vanderbilt University Medical Center

    Nashville, Tennessee, United States

  • University of North Texas Science Center at Fort Worth

    Fort Worth, Texas, United States

  • Clinical Trials of Texas

    San Antonio, Texas, United States

  • Physician'S Research Options, Llc/the Intermountain Spine Institute

    Murray, Utah, United States

  • University of Utah

    Salt Lake City, Utah, United States

  • University of Virginia

    Charlottesville, Virginia, United States

  • Harborview Medical Center

    Seattle, Washington, United States

  • Virginia Mason Medical Center

    Seattle, Washington, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Thrombin
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
31 Oct 2005
Primary completion
30 Jun 2006
Completion
31 Jul 2006
Last update posted
9 Mar 2009
Registered enrollment
401
Registry id
NCT00245336

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.