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Clinical trialNCT00248651CompletedPhase 2/PHASE3Interventional

Functional Dyspepsia Treatment Trial

SponsorMayo ClinicEnrollment292Dyspepsia and Other Specified Disorders of Function of Stomach
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

Functional dyspepsia is a common gastrointestinal disorder. Symptoms can include stomach pain or discomfort, bloating, fullness after eating meals, and nausea. These symptoms often interfere with school and work, and weight loss may occur due to dietary restrictions. The hypothesis of this study was that antidepressant therapy is more effective than placebo in relief of the symptoms of functional dyspepsia, adjusting for psychological and psychiatric co-morbidity. The study also examined if antidepressant therapy reduces disability and improves quality of life in functional dyspepsia.
clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

8 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Canada
  • Mcmaster University Centre

    Hamilton, Ontario, Canada

United States
  • Mayo Clinic

    Scottsdale, Arizona, United States

  • Mayo Clinic Jacksonville

    Jacksonville, Florida, United States

  • Northwestern University Chicago

    Chicago, Illinois, United States

  • Mayo Clinic

    Rochester, Minnesota, United States

  • Saint Louis University School of Medicine

    St Louis, Missouri, United States

  • Dartmouth-Hitchcock Medical Center

    Lebanon, New Hampshire, United States

  • Baylor College of Medicine

    Houston, Texas, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Amitriptyline →Escitalopram →Placebo
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
31 Oct 2006
Primary completion
31 Jul 2013
Completion
31 Jul 2013
Last update posted
25 Jul 2014
Registered enrollment
292
Registry id
NCT00248651
clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.