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Clinical trialNCT00262821TerminatedPhase 3Interventional

Cisplatin and Radiation Therapy With or Without Tirapazamine in Treating Patients With Cervical Cancer

SponsorNational Cancer Institute (NCI)Enrollment402Cervical AdenocarcinomaCervical Adenosquamous Cell CarcinomaCervical Squamous Cell CarcinomaStage IB Cervical CancerStage IIA Cervical CancerStage IIB Cervical Cancer+2 more conditions
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This randomized phase III trial is studying cisplatin, radiation therapy, and tirapazamine to see how well they work compared to cisplatin and radiation therapy in treating patients with cervical cancer. Drugs used in chemotherapy, such as cisplatin and tirapazamine, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Radiation therapy uses high-energy x-rays to kill tumor cells. Internal radiation uses radioactive material placed directly into or near a tumor to kill tumor cells. Cisplatin and tirapazamine may make tumor cells more sensitive to radiation therapy. It is not yet known whether giving cisplatin together with radiation therapy is more effective with or without tirapazamine in treating cervical cancer.
clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

282 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Canada
  • Tom Baker Cancer Centre

    Calgary, Alberta, Canada

  • Bcca-Fraser Valley Cancer Centre

    Surrey, British Columbia, Canada

  • Bcca-Vancouver Cancer Centre

    Vancouver, British Columbia, Canada

  • Health Sciences North

    Greater Sudbury, Ontario, Canada

  • Thunder Bay Regional Health Science Centre

    Thunder Bay, Ontario, Canada

  • Odette Cancer Centre- Sunnybrook Health Sciences Centre

    Toronto, Ontario, Canada

  • Chum - Hopital Notre-Dame

    Montreal, Quebec, Canada

  • Chuq - Pavilion Hotel-Dieu de Quebec

    Québec, Quebec, Canada

  • Allan Blair Cancer Centre

    Regina, Saskatchewan, Canada

United States
  • University of Alabama at Birmingham

    Birmingham, Alabama, United States

  • Mobile Infirmary Medical Center

    Mobile, Alabama, United States

  • Providence Alaska Medical Center

    Anchorage, Alaska, United States

  • Banner Good Samaritan Medical Center

    Phoenix, Arizona, United States

  • Western Regional Ccop

    Phoenix, Arizona, United States

  • Highlands Oncology Group Pa - Fayetteville

    Fayetteville, Arkansas, United States

  • Washington Regional Medical Center - Fayetteville

    Fayetteville, Arkansas, United States

  • University of Arkansas for Medical Sciences

    Little Rock, Arkansas, United States

  • East Bay Radiation Oncology Center

    Castro Valley, California, United States

  • City of Hope Medical Center

    Duarte, California, United States

  • Jonsson Comprehensive Cancer Center

    Los Angeles, California, United States

  • Bay Area Tumor Institute Ccop

    Oakland, California, United States

  • University of California Medical Center at Irvine-Orange Campus

    Orange, California, United States

  • Pomona Valley Hospital Medical Center

    Pomona, California, United States

  • Stanford University Hospitals and Clinics

    Stanford, California, United States

  • Olive View-University of California Los Angeles Medical Center

    Sylmar, California, United States

  • Colorado Gynecologic Oncology Group

    Aurora, Colorado, United States

  • Memorial Hospital Colorado Springs

    Colorado Springs, Colorado, United States

  • North Colorado Medical Center

    Greeley, Colorado, United States

  • Mckee Medical Center

    Loveland, Colorado, United States

  • Hartford Hospital

    Hartford, Connecticut, United States

  • the Hospital of Central Connecticut

    New Britain, Connecticut, United States

  • Yale University

    New Haven, Connecticut, United States

  • Beebe Medical Center

    Lewes, Delaware, United States

  • Christiana Care Health System-Christiana Hospital

    Newark, Delaware, United States

  • Washington Hospital Center

    Washington D.C., District of Columbia, United States

  • Florida Gynecologic Oncology

    Fort Myers, Florida, United States

  • Mayo Clinic in Florida

    Jacksonville, Florida, United States

  • Uf Cancer Center at Orlando Health

    Orlando, Florida, United States

  • Northside Hospital

    Atlanta, Georgia, United States

  • Piedmont Hospital

    Atlanta, Georgia, United States

242 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Cisplatin →Tirapazamine
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
28 Feb 2006
Primary completion
31 Aug 2010
Completion
31 Aug 2010
Last update posted
23 Jul 2019
Registered enrollment
402
Registry id
NCT00262821
clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.