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Clinical trialNCT00276731UnknownPhase 3Interventional

Combination Chemotherapy Followed By Surgery With or Without Radiation Therapy in Treating Young Patients With Stage II or Stage III Neuroblastoma

SponsorChildren's Cancer and Leukaemia GroupNeuroblastoma
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) may kill more tumor cells. Giving combination chemotherapy before surgery may make the tumor smaller and reduce the amount of normal tissue that needs to be removed. Radiation therapy uses high-energy x-rays to kill tumor cells. Giving radiation therapy after surgery may kill any tumor cells that remain. It is not yet know whether combination chemotherapy followed by surgery alone is more effective than combination chemotherapy followed by surgery and radiation therapy in treating neuroblastoma. PURPOSE: This randomized phase III trial is studying combination chemotherapy followed by surgery to see how well it works compared to combination chemotherapy followed by surgery and radiation therapy in treating young patients with stage II or stage III neuroblastoma.

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

22 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Ireland
  • Our Lady'S Hospital for Sick Children

    Dublin, Ireland

United Kingdom
  • Birmingham Children'S Hospital

    Birmingham, England, United Kingdom

  • Institute of Child Health at University of Bristol

    Bristol, England, United Kingdom

  • Addenbrooke'S Hospital at Cambridge University Hospitals Nhs Foundation Trust

    Cambridge, England, United Kingdom

  • Leeds Cancer Centre at St. James'S University Hospital

    Leeds, England, United Kingdom

  • Leicester Royal Infirmary

    Leicester, England, United Kingdom

  • Royal Liverpool Children'S Hospital, Alder Hey

    Liverpool, England, United Kingdom

  • Great Ormond Street Hospital for Children Nhs Trust

    London, England, United Kingdom

  • Royal London Hospital

    London, England, United Kingdom

  • Central Manchester and Manchester Children'S University Hospitals Nhs Trust

    Manchester, England, United Kingdom

  • Sir James Spence Institute of Child Health

    Newcastle upon Tyne, England, United Kingdom

  • Queen'S Medical Centre

    Nottingham, England, United Kingdom

  • Oxford Radcliffe Hospital

    Oxford, England, United Kingdom

  • Children'S Hospital - Sheffield

    Sheffield, England, United Kingdom

  • Southampton General Hospital

    Southampton, England, United Kingdom

  • Royal Marsden Nhs Foundation Trust - Surrey

    Sutton, England, United Kingdom

  • Royal Belfast Hospital for Sick Children

    Belfast, Northern Ireland, United Kingdom

  • Royal Aberdeen Children'S Hospital

    Aberdeen, Scotland, United Kingdom

  • Royal Hospital for Sick Children

    Edinburgh, Scotland, United Kingdom

  • Beatson Oncology Centre

    Glasgow, Scotland, United Kingdom

  • Royal Hospital for Sick Children

    Glasgow, Scotland, United Kingdom

  • Childrens Hospital for Wales

    Cardiff, Wales, United Kingdom

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
31 Mar 1995
Primary completion
—
Completion
—
Last update posted
17 Sept 2013
Registered enrollment
—
Registry id
NCT00276731

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.