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Clinical trialNCT00276757CompletedInterventional

Combination Chemotherapy in Treating Young Patients With Langerhans Cell Histiocytosis

SponsorHistiocyte SocietyEnrollment376Childhood Langerhans Cell Histiocytosis
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of Langerhans cell histiocytosis, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) may be an effective treatment for Langerhans cell histiocytosis. PURPOSE: This randomized clinical trial is studying combination chemotherapy to see how well it works in treating young patients with Langerhans cell histiocytosis.

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

33 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Argentina
  • Hospital de Pediatria Garrahan

    Buenos Aires, Buenos Aires, Argentina

Austria
  • St. Anna Children'S Hospital

    Vienna, Austria

Canada
  • Hospital for Sick Children

    Toronto, Ontario, Canada

France
  • Chr Hotel Dieu

    Nantes, France

Germany
  • University Medical Center Hamburg - Eppendorf

    Hamburg, Germany

Ireland
  • Our Lady'S Hospital for Sick Children Crumlin

    Dublin, Ireland

Italy
  • Fondazione I.R.C.C.S. Policlinico San Matteo

    Pavia, Italy

Sweden
  • Karolinska University Hospital - Solna

    Stockholm, Sweden

United Kingdom
  • Birmingham Children'S Hospital

    Birmingham, England, United Kingdom

  • Institute of Child Health at University of Bristol

    Bristol, England, United Kingdom

  • Addenbrooke'S Hospital

    Cambridge, England, United Kingdom

  • Leeds Cancer Centre at St. James'S University Hospital

    Leeds, England, United Kingdom

  • Children'S Cancer and Leukaemia Group

    Leicester, England, United Kingdom

  • Leicester Royal Infirmary

    Leicester, England, United Kingdom

  • Royal Liverpool Children'S Hospital, Alder Hey

    Liverpool, England, United Kingdom

  • Great Ormond Street Hospital for Children

    London, England, United Kingdom

  • Royal London Hospital

    London, England, United Kingdom

  • Royal Manchester Children'S Hospital

    Manchester, England, United Kingdom

  • Sir James Spence Institute of Child Health at Royal Victoria Infirmary

    Newcastle upon Tyne, England, United Kingdom

  • Queen'S Medical Centre

    Nottingham, England, United Kingdom

  • Oxford Radcliffe Hospital

    Oxford, England, United Kingdom

  • Children'S Hospital - Sheffield

    Sheffield, England, United Kingdom

  • Southampton General Hospital

    Southampton, England, United Kingdom

  • Royal Marsden - Surrey

    Sutton, England, United Kingdom

  • Royal Belfast Hospital for Sick Children

    Belfast, Northern Ireland, United Kingdom

  • Royal Aberdeen Children'S Hospital

    Aberdeen, Scotland, United Kingdom

  • Royal Hospital for Sick Children

    Edinburgh, Scotland, United Kingdom

  • Royal Hospital for Sick Children

    Glasgow, Scotland, United Kingdom

  • Childrens Hospital for Wales

    Cardiff, Wales, United Kingdom

United States
  • Masonic Cancer Center at University of Minnesota

    Minneapolis, Minnesota, United States

  • Cincinnati Children'S Hospital Medical Center

    Cincinnati, Ohio, United States

  • Vanderbilt Children'S Hospital

    Nashville, Tennessee, United States

  • Texas Children'S Cancer Center and Hematology Service at Texas Children'S Hospital

    Houston, Texas, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
30 Apr 2001
Primary completion
—
Completion
30 Jun 2013
Last update posted
10 Jan 2014
Registered enrollment
376
Registry id
NCT00276757

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.