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Clinical trialNCT00282308CompletedPhase 2Interventional

A Study to Evaluate the Effects of Rituximab on Immune Responses in Subjects With Active Rheumatoid Arthritis Receiving Background Methotrexate

SponsorGenentech, Inc.Enrollment103Rheumatoid Arthritis
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This was a Phase II, randomized, open-label, multicenter study designed to evaluate the immune response to vaccines after administration of 1000 mg of rituximab in subjects with active rheumatoid arthritis (RA) who were receiving background methotrexate (MTX).

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

34 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States
  • Univ of Alabama at Birmingham

    Birmingham, Alabama, United States

  • Arizona Arthritis & Rheumatology Research, Pllc

    Paradise Valley, Arizona, United States

  • Sun Valley Arthritis Center

    Peoria, Arizona, United States

  • Desert Medical Advances

    Palm Desert, California, United States

  • Inland Rheumatology; Clinical Trials, Inc.

    Upland, California, United States

  • Arthritis Associates of South Florida

    Delray Beach, Florida, United States

  • the Arthritis Center

    Palm Harbor, Florida, United States

  • Center for Arthritis; Research Dept

    South Miami, Florida, United States

  • Intermountain Orthopaedics

    Boise, Idaho, United States

  • Northwestern University

    Chicago, Illinois, United States

  • Univ of Chicago

    Chicago, Illinois, United States

  • Evanston Northwestern Healthcare

    Evanston, Illinois, United States

  • Springfield Clinic

    Springfield, Illinois, United States

  • Kentuckiana Center for Better Bone & Joint Healthx

    Louisville, Kentucky, United States

  • Clinical Research Network

    Slidell, Louisiana, United States

  • Johns Hopkins University; Rheumatology

    Baltimore, Maryland, United States

  • Dana Farber Cancer Institute

    Boston, Massachusetts, United States

  • Borgess Research Institute

    Kalamazoo, Michigan, United States

  • Rheumatology, P.C.; Medical Arts Building

    Kalamazoo, Michigan, United States

  • Justus Fiechtner Md - Pp

    Lansing, Michigan, United States

  • Center for Rheumatology, State Uni. of New York

    Albany, New York, United States

  • Aair Research Center

    Rochester, New York, United States

  • University of Rochester - Strong Memorial Hospital

    Rochester, New York, United States

  • Physicians East Pa

    Greenville, North Carolina, United States

  • Health Research of Oklahoma, Llc

    Oklahoma City, Oklahoma, United States

  • Oregon Health Sciences Uni

    Portland, Oregon, United States

  • Altoona Arthritis & Osteo Center

    Duncansville, Pennsylvania, United States

  • University of Pennsylvania

    Philadelphia, Pennsylvania, United States

  • Medical University of S. Carolina

    Charleston, South Carolina, United States

  • Rheumatology Associates

    Charleston, South Carolina, United States

  • Arthritis Associates

    Hixson, Tennessee, United States

  • Arthritis Care & Diagnostic Center

    Dallas, Texas, United States

  • Arthritis Clinic of Northern Virginia

    Arlington, Virginia, United States

  • Arthritis Northwest, Spokane

    Spokane, Washington, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Pneumococcal 23-valent polysaccharide vaccineC. albicansKeyhole limpet hemocyaninMethotrexate6-MethylprednisoneRituximabTetanus toxoid adsorbed booster vaccine
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
23 Jan 2006
Primary completion
31 Jan 2008
Completion
28 May 2012
Last update posted
10 Aug 2017
Registered enrollment
103
Registry id
NCT00282308

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 4 Nov 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.