Clinical trialNCT00302341TerminatedPhase 3Interventional

DB289 Versus TMP-SMX for the Treatment of Acute Pneumocystis Jiroveci Pneumonia (PCP)

SponsorImmtech Pharmaceuticals, IncEnrollment48HIV InfectionsPneumocystis Carinii PneumoniaPneumonia, Interstitial Plasma CellPneumonia, Pneumocystis Carinii

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The purpose of this study is to demonstrate the non-inferiority of pafuramidine maleate (DB289)versus trimethoprim-sulfamethoxazole (TMP-SMX)for the treatment of mild to moderately severe Pneumocystis pneumonia (PCP).

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Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

Amanda Peppercorn, MD
UNC AIDS Clinical Trials- School of Medicine
Principal Investigator
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Carl Fichtenbaum, MD
University of Cincinnati
Principal Investigator
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Jose Vazquez, MD
Henry Ford Health Systems
Principal InvestigatorKOL profile →
clinicaltrials.gov ↗
Judith Aberg, MD
NYU School of Medicine
Principal InvestigatorKOL profile →
clinicaltrials.gov ↗
Kathleen Mullane, DO
University of Chicago
Principal Investigator
clinicaltrials.gov ↗
Laurence Huang, MD
University of California, San Francisco
Principal Investigator
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Preston Church, MD
Medical University of South Carolina
Principal Investigator
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A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

7 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

University of California
San Francisco, California, United States
the University of Chicago
Chicago, Illinois, United States
Henry Ford Health System
Detroit, Michigan, United States
Nyu School of Medicine
New York, New York, United States
Unc Aids Clinical Trials
Chapel Hill, North Carolina, United States
University of Cincinnati
Cincinnati, Ohio, United States
Medical University of Sc
Charleston, South Carolina, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Pafuramidine maleateSulfamethoxazole / trimethoprim

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 31 May 2006
Primary completion: 31 Dec 2008
Completion: 31 Dec 2008
Last update posted: 7 Mar 2013
Registered enrollment: 48
Registry id: NCT00302341

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 4 Nov 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.