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Clinical trialNCT00322673TerminatedPhase 2Interventional

Study of XL999 in Patients With Acute Myeloid Leukemia (AML)

SponsorSymphony Evolution, Inc.Enrollment14AMLAcute Myeloid Leukemia
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This clinical study is being conducted at multiple sites to determine the activity, safety and tolerability of XL999 when given weekly to patients with relapsed or newly-diagnosed AML. XL999 is a small molecule inhibitor against Flk1/kinase insert domain receptor (KDR), PDGFR, c-Kit, FLT3 and SRC. c-Kit and FLT3 are receptors commonly expressed on AML blasts.
clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

7 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States
  • Eddie Hu

    Alhambra, California, United States

  • Ronald Paquette

    Los Angeles, California, United States

  • the Thomas and Dorothy Leavey Cancer Center

    Northridge, California, United States

  • David Chan

    Redondo Beach, California, United States

  • Northwestern University Feinberg School of Medicine, Division of Hematology/oncology

    Chicago, Illinois, United States

  • American Health Network of Indiana

    Indianapolis, Indiana, United States

  • Section of Hematology/oncology Indiana Cancer Pavilion

    Indianapolis, Indiana, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

XL999
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
31 May 2006
Primary completion
30 Nov 2006
Completion
31 May 2007
Last update posted
22 Feb 2010
Registered enrollment
14
Registry id
NCT00322673
clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.