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Clinical trialNCT00336024CompletedPhase 3Interventional

Combination Chemotherapy Followed By Peripheral Stem Cell Transplant in Treating Young Patients With Newly Diagnosed Supratentorial Primitive Neuroectodermal Tumors or High-Risk Medulloblastoma

SponsorChildren's Oncology GroupEnrollment91Anaplastic MedulloblastomaMedulloblastomaSupratentorial Embryonal Tumor, Not Otherwise SpecifiedUntreated Childhood Supratentorial Primitive Neuroectodermal Tumor
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This randomized phase III trial is studying two different combination chemotherapy regimens to compare how well they work in treating young patients with newly diagnosed supratentorial primitive neuroectodermal tumors or high-risk medulloblastoma when given before additional intense chemotherapy followed by peripheral blood stem cell rescue. It is not yet known which combination chemotherapy regimen is more effective when given before a peripheral stem cell transplant in treating supratentorial primitive neuroectodermal tumors or medulloblastoma.

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

145 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Australia
  • Sydney Children'S Hospital

    Randwick, New South Wales, Australia

  • the Children'S Hospital at Westmead

    Westmead, New South Wales, Australia

  • Royal Children'S Hospital

    Parkville, Victoria, Australia

  • Princess Margaret Hospital for Children

    Perth, Western Australia, Australia

Canada
  • Alberta Children'S Hospital

    Calgary, Alberta, Canada

  • British Columbia Children'S Hospital

    Vancouver, British Columbia, Canada

  • Cancercare Manitoba

    Winnipeg, Manitoba, Canada

  • Iwk Health Centre

    Halifax, Nova Scotia, Canada

  • Mcmaster Children'S Hospital at Hamilton Health Sciences

    Hamilton, Ontario, Canada

  • Kingston Health Sciences Centre

    Kingston, Ontario, Canada

  • Children'S Hospital of Eastern Ontario

    Ottawa, Ontario, Canada

  • Hospital for Sick Children

    Toronto, Ontario, Canada

  • Centre Hospitalier Universitaire Sainte-Justine

    Montreal, Quebec, Canada

  • the Montreal Children'S Hospital of the Muhc

    Montreal, Quebec, Canada

  • Chu de Quebec-Centre Hospitalier de L'Universite Laval (chul)

    Québec, Canada

Puerto Rico
  • San Jorge Children'S Hospital

    San Juan, Puerto Rico

United States
  • Children'S Hospital of Alabama

    Birmingham, Alabama, United States

  • University of Alabama at Birmingham Cancer Center

    Birmingham, Alabama, United States

  • Phoenix Childrens Hospital

    Phoenix, Arizona, United States

  • Arkansas Children'S Hospital

    Little Rock, Arkansas, United States

  • University of Arkansas for Medical Sciences

    Little Rock, Arkansas, United States

  • Kaiser Permanente Downey Medical Center

    Downey, California, United States

  • Loma Linda University Medical Center

    Loma Linda, California, United States

  • Miller Children'S and Women'S Hospital Long Beach

    Long Beach, California, United States

  • Cedars Sinai Medical Center

    Los Angeles, California, United States

  • Children'S Hospital Los Angeles

    Los Angeles, California, United States

  • Valley Children'S Hospital

    Madera, California, United States

  • Children'S Hospital of Orange County

    Orange, California, United States

  • Sutter Medical Center Sacramento

    Sacramento, California, United States

  • University of California Davis Comprehensive Cancer Center

    Sacramento, California, United States

  • Rady Children'S Hospital - San Diego

    San Diego, California, United States

  • Ucsf Medical Center-Parnassus

    San Francisco, California, United States

  • Children'S Hospital Colorado

    Aurora, Colorado, United States

  • Connecticut Children'S Medical Center

    Hartford, Connecticut, United States

  • Alfred I Dupont Hospital for Children

    Wilmington, Delaware, United States

  • Children'S National Medical Center

    Washington D.C., District of Columbia, United States

  • Broward Health Medical Center

    Fort Lauderdale, Florida, United States

  • Golisano Children'S Hospital of Southwest Florida

    Fort Myers, Florida, United States

  • Lee Memorial Health System

    Fort Myers, Florida, United States

  • University of Florida Health Science Center - Gainesville

    Gainesville, Florida, United States

105 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
22 Oct 2007
Primary completion
31 Dec 2016
Completion
30 Sept 2025
Last update posted
23 Jan 2026
Registered enrollment
91
Registry id
NCT00336024

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.