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Clinical trialNCT00341705CompletedObservational

The Second Multicenter Hemophilia Cohort Study

SponsorNational Cancer Institute (NCI)Enrollment2,565Hepatocellular CarcinomaLiver DecompensationNon-Hodgkin Lymphoma
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The Second Multicenter Hemophilia Cohort Study (MHCS-II) will evaluate and prospectively follow approximately 4500 persons with hemophilia who were exposed to hepatitis C virus (HCV). The vast majority will have been infected with HCV, and approximately 1/3 will have been infected with human immunodeficiency virus (HIV). Primary objectives are to quantify the rates of liver decompensation, hepatocellular carcinoma, and non-Hodgkin lymphoma and to evaluate candidate clinical, genetic, virologic, serologic and immunologic markers that are likely to be on the causal pathway for these conditions. Candidate clinical and laboratory markers will be examined longitudinally to define changes over time and their relationships to one another. Collaborative studies will focus on genome scanning and evaluation of candidate genetic loci for susceptibility or resistance to HCV and HIV infections or to the diseases that result from these infections. Additional studies will identify response and complication rates of various anti-HCV and anti-HIV regimens in the setting of comprehensive clinical care of persons with hemophilia.
clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

48 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Brazil
  • Hospital Brigadeiro

    São Paulo, Brazil

  • University of Sao Paulo

    São Paulo, Brazil

Canada
  • South East Health Care Corporation

    New Brunswick, Canada

France
  • Hospices Civils de Lyon

    Lyon, France

Germany
  • University of Bonn

    Bonn, Germany

Greece
  • Laikon General Hospital of Athens

    Athens, Greece

Italy
  • University of Florence

    Florence, Italy

  • University de Milano

    Milan, Italy

Sweden
  • Karolinska Institute St. Gorans Hospital

    Stockholm, Sweden

United States
  • University of Arizona

    Tucson, Arizona, United States

  • University of California, Davis

    Davis, California, United States

  • Children'S Hospital of Orange County

    Orange, California, United States

  • University of California, San Francisco

    San Francisco, California, United States

  • University of Colorado

    Denver, Colorado, United States

  • Christiana Hospital

    Wilmington, Delaware, United States

  • Childrens National Medical Center

    Washington D.C., District of Columbia, United States

  • Georgetown University

    Washington D.C., District of Columbia, United States

  • Emory University

    Atlanta, Georgia, United States

  • Childrens Memorial Hospital, Chicago

    Chicago, Illinois, United States

  • University of Illinois

    Chicago, Illinois, United States

  • St. Vincent'S Hospital

    Indianapolis, Indiana, United States

  • Tulane University

    New Orleans, Louisiana, United States

  • Wayne State University Hutzel Hospital

    Detroit, Michigan, United States

  • University of Minnesota

    Minneapolis, Minnesota, United States

  • University of Mississippi

    Jackson, Mississippi, United States

  • St. Louis University

    St Louis, Missouri, United States

  • University of New Mexico

    Albuquerque, New Mexico, United States

  • University of Buffalo

    Buffalo, New York, United States

  • North Shore Long Island Jewish Health System

    Lake Success, New York, United States

  • Cornell University

    New York, New York, United States

  • Mt. Sinai Medical Center

    New York, New York, United States

  • University of North Carolina

    Chapel Hill, North Carolina, United States

  • Wake Forest University

    Winston-Salem, North Carolina, United States

  • Childrens Hospital, Cinncinati

    Cincinnati, Ohio, United States

  • University of Cincinnati

    Cincinnati, Ohio, United States

  • Ohio State University

    Columbus, Ohio, United States

  • Wright State University

    Dayton, Ohio, United States

  • University of Oklahoma

    Oklahoma City, Oklahoma, United States

  • Milton Hershey Medical Center

    Hershey, Pennsylvania, United States

  • Thomas Jefferson University

    Philadelphia, Pennsylvania, United States

8 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

No drug or biological interventions are in our data for this study. It may test a procedure, device or behavioral intervention, or the intervention list isn't in our current snapshot. See the registry record ↗. Why? →

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
27 Apr 2001
Primary completion
—
Completion
2 Apr 2013
Last update posted
17 Dec 2019
Registered enrollment
2,565
Registry id
NCT00341705
clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 4 Nov 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.