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Clinical trialNCT00357552CompletedInterventional

Safety and Effectiveness of Lopinavir/Ritonavir in Individuals Who Have Failed Prior HIV Therapy

SponsorAdvancing Clinical Therapeutics Globally for HIV/AIDS and Other InfectionsEnrollment123HIV Infections
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

Most anti-HIV regimens include a non-nucleoside reverse transcriptase inhibitor (NNRTI); however, some individuals fail on these regimens. The purpose of this study is to evaluate the safety and effectiveness of the protease inhibitor (PI) lopinavir/ritonavir (LPV/r) in HIV infected individuals who are failing an anti-HIV regimen that includes an NNRTI.
clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

  • John Bartlett, MD

    Division of Infectious Diseases, Duke University Medical Center

    Study Chair
    clinicaltrials.gov ↗
  • Nagalingeswaran Kumarasamy, MBBS, PhD

    Y. R. Gaitonde Centre for AIDS Research and Education

    Study Chair
    clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

5 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

India
  • Y.R.G Ctr, for Aids Research and Education (11701)

    Chennai, India

Malawi
  • University of North Carolina Lilongwe Crs (12001)

    Lilongwe, Malawi

South Africa
  • Wits Hiv Crs (11101)

    Johannesburg, Gauteng, South Africa

Tanzania
  • Kilimanjaro Christian Medical Crs

    Moshi, Tanzania

Thailand
  • Chiang Mai University Actg Crs (11501)

    Chiang Mai, Thailand

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Emtricitabine →Lopinavir →
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
31 Jan 2008
Primary completion
31 Oct 2010
Completion
31 May 2012
Last update posted
20 Mar 2018
Registered enrollment
123
Registry id
NCT00357552
clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.