findmyKOL
Clinical trialNCT00367770CompletedPhase 4Interventional

BREATHE 5-OL: Tracleer (Bosentan) in Patients With Pulmonary Arterial Hypertension Related to Eisenmenger Physiology

SponsorActelionEnrollment37Pulmonary Arterial Hypertension
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This 6-month open label study will evaluate the long term safety of bosentan (via oxygen saturation) and efficacy (exercise capacity) in patients who have completed the BREATHE-5 study (PAH related to Eisenmenger physiology). Treatment duration is 6 months.
clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

17 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Australia
  • Royal Prince Alfred Hospital - Central Clinical School

    Camperdown, Australia

  • the Royal Melbourne Hospital

    Victoria, Australia

Austria
  • Universitatsklinikum Fur Innere Medizin Ii

    Vienna, Austria

Belgium
  • Uz Gasthuisberg

    Leuven, Belgium

Canada
  • the Peter Lougheed Centre

    Calgary, Alberta, Canada

  • Toronto General Hospital

    Toronto, Ontario, Canada

France
  • Hospital Necker-Enfants Malades

    Paris, France

Germany
  • Herzzentrum Nrw

    Bad Oeynhausen, Germany

  • Deutsches Herzzentrum Munchen

    München, Germany

Italy
  • University of Bologna

    Bologna, Italy

  • San Matteo Hospital

    Pavia, Italy

Netherlands
  • Academisch Ziekenhuis Groningen

    Groningen, Netherlands

Spain
  • Unidad Medico Quirurgica de Cardiologia - Edificio General

    Madrid, Spain

United Kingdom
  • Scottish Vascular Unit - Western Infirmary

    Glasgow, United Kingdom

  • Royal Brompton Hospital

    London, United Kingdom

United States
  • Bach Pulmonary Hypertension Service

    Boston, Massachusetts, United States

  • Texas Children'S Hospital

    Houston, Texas, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Tracleer®
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
31 Jan 2004
Primary completion
31 Dec 2005
Completion
31 Dec 2005
Last update posted
22 Sept 2016
Registered enrollment
37
Registry id
NCT00367770
clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.