Clinical trialNCT00369122CompletedPhase 2Interventional

Bevacizumab, Radiation Therapy, and Cisplatin in Treating Patients With Previously Untreated Locally Advanced Cervical Cancer

SponsorNational Cancer Institute (NCI)Enrollment60Cervical AdenocarcinomaCervical Adenosquamous CarcinomaCervical Squamous Cell Carcinoma, Not Otherwise SpecifiedStage IB Cervical Cancer AJCC v6 and v7Stage IIA Cervical Cancer AJCC v7Stage IIB Cervical Cancer AJCC v6 and v7+1 more conditions

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This phase II trial is studying how well giving bevacizumab together with radiation therapy and cisplatin works in treating patients with previously untreated locally advanced cervical cancer. Monoclonal antibodies, such as bevacizumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. Bevacizumab may also stop the growth of cervical cancer by blocking blood flow to the tumor. Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs used in chemotherapy, such as cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving bevacizumab together with radiation therapy and cisplatin may kill more tumor cells.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

Tracey Schefter
Radiation Therapy Oncology Group
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

106 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Canada

London Regional Cancer Program
London, Ontario, Canada
Mcgill University Department of Oncology
Montreal, Quebec, Canada
Allan Blair Cancer Centre
Regina, Saskatchewan, Canada

United States

Providence Saint Joseph Medical Center/disney Family Cancer Center
Burbank, California, United States
University of California Davis Comprehensive Cancer Center
Sacramento, California, United States
Penrose-Saint Francis Healthcare
Colorado Springs, Colorado, United States
University of Colorado
Denver, Colorado, United States
Baptist Md Anderson Cancer Center
Jacksonville, Florida, United States
Baptist Medical Center South
Jacksonville, Florida, United States
Integrated Community Oncology Network-Southside Cancer Center
Jacksonville, Florida, United States
University of Florida Health Science Center - Jacksonville
Jacksonville, Florida, United States
Integrated Community Oncology Network-Florida Cancer Center Beaches
Jacksonville Beach, Florida, United States
21st Century Oncology-Orange Park
Orange Park, Florida, United States
Uf Cancer Center at Orlando Health
Orlando, Florida, United States
21st Century Oncology-Palatka
Palatka, Florida, United States
Bay Medical Center
Panama City, Florida, United States
Integrated Community Oncology Network-Flager Cancer Center
Saint Augustine, Florida, United States
Emory University Hospital/winship Cancer Institute
Atlanta, Georgia, United States
Grady Health System
Atlanta, Georgia, United States
Northwest Community Hospital
Arlington Heights, Illinois, United States
John H Stroger Jr Hospital of Cook County
Chicago, Illinois, United States
Northwestern University
Chicago, Illinois, United States
Franciscan St. James Health-Olympia Fields Campus
Olympia Fields, Illinois, United States
Methodist Medical Center of Illinois
Peoria, Illinois, United States
Saint Vincent Anderson Regional Hospital/cancer Center
Anderson, Indiana, United States
Franciscan Saint Francis Health-Beech Grove
Beech Grove, Indiana, United States
Saint Vincent Hospital and Health Care Center
Indianapolis, Indiana, United States
Reid Health
Richmond, Indiana, United States
Providence Medical Center
Kansas City, Kansas, United States
Lawrence Memorial Hospital
Lawrence, Kansas, United States
Menorah Medical Center
Overland Park, Kansas, United States
Radiation Oncology Practice Corporation Southwest
Overland Park, Kansas, United States
Saint Luke'S South Hospital
Overland Park, Kansas, United States
Shawnee Mission Medical Center-Kccc
Shawnee Mission, Kansas, United States
Baptist Health Lexington
Lexington, Kentucky, United States
Norton Suburban Hospital and Medical Campus
Louisville, Kentucky, United States
Boston Medical Center
Boston, Massachusetts, United States
Brigham and Women'S Hospital
Boston, Massachusetts, United States
University of Michigan Comprehensive Cancer Center
Ann Arbor, Michigan, United States
Borgess Medical Center
Kalamazoo, Michigan, United States

66 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Bevacizumab →Cisplatin →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 11 Aug 2006
Primary completion: 4 Jun 2010
Completion: 15 Dec 2016
Last update posted: 20 Mar 2018
Registered enrollment: 60
Registry id: NCT00369122

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 4 Nov 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.