Clinical trialNCT00369564CompletedPhase 3Interventional

Glutamic Acid in Reducing Nerve Damage Caused by Vincristine in Young Patients With Cancer

SponsorUniversity of South FloridaEnrollment250Kidney CancerLeukemiaLymphomaNeurotoxicityPeripheral NeuropathySarcoma

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

RATIONALE: Glutamic acid may help lessen or prevent nerve damage caused by vincristine. It is not yet known whether glutamic acid is more effective than a placebo in preventing nerve damage in patients receiving vincristine for Wilms' tumor, rhabdomyosarcoma, acute lymphoblastic leukemia, or non-Hodgkin's lymphoma. PURPOSE: This randomized phase III trial is studying glutamic acid to see how well it works compared to a placebo in reducing nerve damage caused by vincristine in young patients receiving vincristine for Wilms' tumor, rhabdomyosarcoma, acute lymphoblastic leukemia, or non-Hodgkin's lymphoma.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

David R. Freyer, DO, MS
Wake Forest University Health Sciences
Study Chair
clinicaltrials.gov ↗
Eric Sandler, MD
Nemours Children's Clinic
Study Chair
clinicaltrials.gov ↗
Scott Bradfield, MD
Nemours Children's Clinic
Study Chair
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

6 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Lee Cancer Care of Lee Memorial Health System
Fort Myers, Florida, United States
Butterworth Hospital at Spectrum Health
Grand Rapids, Michigan, United States
Children'S Hospitals and Clinics of Minnesota - Minneapolis
Minneapolis, Minnesota, United States
Hackensack University Medical Center Cancer Center
Hackensack, New Jersey, United States
Blumenthal Cancer Center at Carolinas Medical Center
Charlotte, North Carolina, United States
Nationwide Children'S Hospital
Columbus, Ohio, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Glutamate

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 31 May 2007
Primary completion: 30 Nov 2012
Completion: 30 Nov 2012
Last update posted: 11 Aug 2021
Registered enrollment: 250
Registry id: NCT00369564

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.