Clinical trialNCT00376961CompletedPhase 2Interventional

S0601 Rituximab, Combination Chemotherapy, and Bortezomib Followed by Bortezomib Alone in Treating Patients With Newly Diagnosed Mantle Cell Lymphoma

SponsorSWOG Cancer Research NetworkEnrollment68Lymphoma

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

RATIONALE: Monoclonal antibodies, such as rituximab, can block cancer growth in different ways. Some block the ability of cancer cells to grow and spread. Others find cancer cells and help kill them or carry cancer-killing substances to them. Drugs used in chemotherapy work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Bortezomib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Giving rituximab together with combination chemotherapy and bortezomib may kill more cancer cells. Giving bortezomib as maintenance therapy may keep the cancer from progressing. PURPOSE: This phase II trial is studying how well giving rituximab together with combination chemotherapy and bortezomib followed by bortezomib alone works in treating patients with newly diagnosed mantle cell lymphoma.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

Richard I. Fisher, MD
James P. Wilmot Cancer Center
Study Chair
clinicaltrials.gov ↗
Steven H. Bernstein, MD
James P. Wilmot Cancer Center
Study Chair
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

147 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Alaska Regional Hospital Cancer Center
Anchorage, Alaska, United States
Providence Cancer Center
Anchorage, Alaska, United States
Arizona Cancer Center at University of Arizona Health Sciences Center
Tucson, Arizona, United States
Arkansas Cancer Research Center at University of Arkansas for Medical Sciences
Little Rock, Arkansas, United States
Providence Saint Joseph Medical Center - Burbank
Burbank, California, United States
North Bay Cancer Center
Fairfield, California, United States
Poudre Valley Hospital
Fort Collins, Colorado, United States
Broward General Medical Center Cancer Center
Fort Lauderdale, Florida, United States
M.D. Anderson Cancer Center at Orlando
Orlando, Florida, United States
Mountain States Tumor Institute at St. Luke'S Regional Medical Center
Boise, Idaho, United States
Decatur Memorial Hospital Cancer Care Institute
Decatur, Illinois, United States
St. Francis Hospital and Health Centers - Beech Grove Campus
Beech Grove, Indiana, United States
Reid Hospital & Health Care Services
Richmond, Indiana, United States
Cancer Center of Kansas, Pa - Chanute
Chanute, Kansas, United States
Cancer Center of Kansas, Pa - Dodge City
Dodge City, Kansas, United States
Cancer Center of Kansas, Pa - El Dorado
El Dorado, Kansas, United States
Kansas Masonic Cancer Research Institute at the University of Kansas Medical Center
Kansas City, Kansas, United States
Cancer Center of Kansas, Pa - Kingman
Kingman, Kansas, United States
Southwest Medical Center
Liberal, Kansas, United States
Cancer Center of Kansas, Pa - Newton
Newton, Kansas, United States
Olathe Cancer Center
Olathe, Kansas, United States
Cancer Center of Kansas, Pa - Parsons
Parsons, Kansas, United States
Cancer Center of Kansas, Pa - Pratt
Pratt, Kansas, United States
Cancer Center of Kansas, Pa - Salina
Salina, Kansas, United States
Tammy Walker Cancer Center at Salina Regional Health Center
Salina, Kansas, United States
Cotton-O'Neil Cancer Center
Topeka, Kansas, United States
St. Francis Comprehensive Cancer Center
Topeka, Kansas, United States
Cancer Center of Kansas, Pa - Wellington
Wellington, Kansas, United States
Associates in Womens Health, Pa - North Review
Wichita, Kansas, United States
Ccop - Wichita
Wichita, Kansas, United States
Cancer Center of Kansas, Pa - Medical Arts Tower
Wichita, Kansas, United States
Cancer Center of Kansas, Pa - Wichita
Wichita, Kansas, United States
Via Christi Cancer Center at Via Christi Regional Medical Center
Wichita, Kansas, United States
Cancer Center of Kansas, Pa - Winfield
Winfield, Kansas, United States
Boston University Cancer Research Center
Boston, Massachusetts, United States
University of Michigan Comprehensive Cancer Center
Ann Arbor, Michigan, United States
Battle Creek Health System Cancer Care Center
Battle Creek, Michigan, United States
Mecosta County Medical Center
Big Rapids, Michigan, United States
Butterworth Hospital at Spectrum Health
Grand Rapids, Michigan, United States
Ccop - Grand Rapids
Grand Rapids, Michigan, United States

107 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

BortezomibCyclophosphamideDoxorubicinPrednisoneRituximabVincristine

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 31 Aug 2006
Primary completion: 31 Dec 2012
Completion: 30 Sept 2017
Last update posted: 6 Nov 2017
Registered enrollment: 68
Registry id: NCT00376961

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 4 Nov 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.