Clinical trialNCT00391872CompletedPhase 3Interventional

A Comparison of Ticagrelor (AZD6140) and Clopidogrel in Patients With Acute Coronary Syndrome

SponsorAstraZenecaEnrollment18,624Acute Coronary Syndrome

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

Ticagrelor is a new, reversible binding, anti-platelet medication. Anti-platelet medications work to prevent the formation of blood clots. Ticagrelor is being developed as a treatment for patients with acute coronary syndrome (ACS). ACS is a term that is used to describe both heart attacks in progress or the imminent threat of a heart attack. ACS is usually caused by the formation of a blood clot in an artery that partially or totally blocks the blood supply to a portion of the heart muscle. Ticagrelor will be compared with clopidogrel to determine which drug, when either is used in conjunction with aspirin, is better at reducing deaths from vascular causes, future heart attacks and/or strokes in patients with ACS.

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Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Jonathan C. Fox, MD
AstraZeneca
Study Director
clinicaltrials.gov ↗
Lars Wallentin, MD
Uppsala Clinical Research Centre
Principal Investigator
clinicaltrials.gov ↗
Robert Harrington, MD
Duke Clinical Research Institute
Principal InvestigatorKOL profile →
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

672 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Argentina

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Adrogué, Buenos Aires, Argentina
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Buenos Aires, Buenos Aires, Argentina
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Capital Federal, Buenos Aires, Argentina
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Ciudad Autonoma de Bs. As., Buenos Aires, Argentina
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Quilmes, Buenos Aires, Argentina
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Corrientes, Corrientes Province, Argentina
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Córdoba, Córdoba Province, Argentina
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Morón, Pcia. de Buenos Aires, Argentina
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Salta, Salta Province, Argentina
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Rosario, Santa Fe Province, Argentina
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Santa Fe, Santa Fe Province, Argentina
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San Miguel de Tucumán, Tucuman - Argentina, Argentina
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San Miguel de Tucumán, Argentina

Australia

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Bruce, Australian Capital Territory, Australia
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Chermside, Queensland, Australia
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Herston, Queensland, Australia
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Woolloongabba, Queensland, Australia
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Bedford Park, South Australia, Australia
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Dandenong, Victoria, Australia
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Geelong, Victoria, Australia
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Melbourne, Victoria, Australia
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Perth, Western Australia, Australia

Austria

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Feldkirch, Austria
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Freistadt, Austria
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Graz, Austria
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Innsbruck, Austria
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Linz, Austria
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Mödling, Austria
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Vienna, Austria
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Villach, Austria

Belgium

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Aalst, Belgium, Belgium
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Bouge, Belgium, Belgium
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Brasschaat, Belgium, Belgium
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Brussels (anderlecht), Belgium, Belgium
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Charleroi, Belgium, Belgium
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Edegem, Belgium, Belgium
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Genk, Belgium, Belgium
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Hasselt, Belgium, Belgium
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Huy, Belgium, Belgium
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Liège, Belgium, Belgium

632 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Clopidogrel →Ticagrelor →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 31 Oct 2006
Primary completion: 31 Mar 2009
Completion: 31 Mar 2009
Last update posted: 13 Mar 2012
Registered enrollment: 18,624
Registry id: NCT00391872

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.