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Clinical trialNCT00399919CompletedPhase 3Interventional

Safety and Efficacy of Propionyl-L-Carnitine in the Treatment of Peripheral Arterial Disease (Intermittent Claudication)

SponsorSigma-Tau Research, Inc.Enrollment69Intermittent ClaudicationPeripheral Vascular Diseases
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

Patients with peripheral artery disease have decreased blood flow to exercising muscle causing pain. This decreased blood flow to the muscle affects the level of acylcarnitines which in turn decreases the level of carnitine. Carnitine allows muscles to function properly. This study will test the safety and efficacy of Propionyl-L-Carnitine taken in combination with a monitored exercise training program.
clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

9 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States
  • Jacksonville Center for Clinical Research

    Jacksonville, Florida, United States

  • Baptist Clinical Research

    Pensacola, Florida, United States

  • Western Suburban Cardiologists, Ltd.

    LaGrange, Illinois, United States

  • Siu School of Medicine

    Springfield, Illinois, United States

  • University of Massachusetts Medical Center

    Worchester, Massachusetts, United States

  • Dartmouth-Hitchcock Medical Center

    Lebanon, New Hampshire, United States

  • University of Rochester Medical Center

    Rochester, New York, United States

  • Asheville Cardiology Associates

    Asheville, North Carolina, United States

  • Durham Va Medical Center

    Durham, North Carolina, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

PLCLevocarnitine propionate
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
30 Apr 2006
Primary completion
31 Mar 2008
Completion
31 Mar 2008
Last update posted
25 Aug 2011
Registered enrollment
69
Registry id
NCT00399919
clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.