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Clinical trialNCT00405704CompletedPhase 3Interventional

Randomized Intervention for Children With Vesicoureteral Reflux (RIVUR)

SponsorNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)Enrollment607Urinary Tract InfectionsVesicoureteral Reflux
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

In this 2-year, multisite, randomized, placebo-controlled trial involving 607 children with vesicoureteral reflux that was diagnosed after a first or second febrile or symptomatic urinary tract infecton, we evaluated the efficacy of Trimethoprim-Sulfamethoxazole (TMP-SMZ) prophylaxis in preventing recurrences (primary outcome). Secondary outcomes were renal scarring, treatment failure (a composite of recurrences and scarring), and antimicrobial resistance.

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

19 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States
  • University of Alabama

    Birmingham, Alabama, United States

  • Alfred I. Dupont Hospital for Children

    Wilmington, Delaware, United States

  • Children'S National Medical Center

    Washington D.C., District of Columbia, United States

  • Ann & Robert Lurie Children'S Hospital of Chicago

    Chicago, Illinois, United States

  • Johns Hopkins School of Medicine

    Baltimore, Maryland, United States

  • Children'S Hospital of Boston

    Boston, Massachusetts, United States

  • Children'S Hospital of Michigan

    Detroit, Michigan, United States

  • Children'S Mercy Hospital

    Kansas City, Missouri, United States

  • Women and Children'S Hospital of Buffalo

    Buffalo, New York, United States

  • Wake Forest University Baptist Medical Center

    Winston-Salem, North Carolina, United States

  • Akron Children'S Hospital

    Akron, Ohio, United States

  • Cincinnati Children'S Hospital

    Cincinnati, Ohio, United States

  • University of Oklahoma

    Oklahoma City, Oklahoma, United States

  • Oregon Health & Science University

    Portland, Oregon, United States

  • Penn State Hershey Medical Center

    Hershey, Pennsylvania, United States

  • Children'S Hospital of Philadelphia

    Philadelphia, Pennsylvania, United States

  • Children'S Hospital of Pittsburgh

    Pittsburgh, Pennsylvania, United States

  • Texas Children'S Hospital

    Houston, Texas, United States

  • University of Wisconsin Children'S Hospital

    Madison, Wisconsin, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

PlaceboSulfamethoxazole / trimethoprim
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
31 May 2007
Primary completion
30 Jun 2013
Completion
31 May 2014
Last update posted
21 Apr 2020
Registered enrollment
607
Registry id
NCT00405704

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.