Clinical trialNCT00445003CompletedPhase 3Interventional

Laser-Ranibizumab-Triamcinolone for Proliferative Diabetic Retinopathy

SponsorJaeb Center for Health ResearchEnrollment333Diabetic Macular EdemaProliferative Diabetic Retinopathy

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The purpose of the study is to find out if treatment with an intravitreal injection of triamcinolone or an intravitreal injection of ranibizumab can prevent loss of vision caused by panretinal photocoagulation treatment. At the present time, it is not known whether intravitreal steroid or anti-vascular endothelial growth factor (anti-VEGF) injections are beneficial in preventing vision loss after panretinal photocoagulation (PRP) treatment. It is possible that one or both of the types of injections will prevent vision loss after PRP treatment. However, it is not known whether the benefits of the injections will outweigh the risks. It is possible that because of side effects, the injections may not be as good as laser alone in treating the diabetic retinopathy.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

Alexander J. Brucker, M.D.
Scheie Eye Institute
Study Chair
clinicaltrials.gov ↗
Joseph Googe, Jr., M.D.
Southeastern Retina Associates, P.C.
Study Chair
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

56 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Sall Research Medical Center
Artesia, California, United States
Retina-Vitreous Associates Medical Group
Beverly Hills, California, United States
University of California, Irvine
Irvine, California, United States
Loma Linda University Health Care, Dept. of Ophthalmology
Loma Linda, California, United States
Southern California Desert Retina Consultants, Mc
Palm Springs, California, United States
California Retina Consultants
Santa Barbara, California, United States
Bay Area Retina Associates
Walnut Creek, California, United States
Eldorado Retina Associates, P.C.
Louisville, Colorado, United States
Retina Vitreous Consultants
Fort Lauderdale, Florida, United States
Retina Consultants of Southwest Florida
Fort Myers, Florida, United States
Central Florida Retina Institute
Lakeland, Florida, United States
Southeast Retina Center, P.C.
Augusta, Georgia, United States
University of Illinois at Chicago Medical Center
Chicago, Illinois, United States
Illinois Retina Associates
Joliet, Illinois, United States
Raj K. Maturi, M.D., P.C.
Indianapolis, Indiana, United States
John-Kenyon American Eye Institute
New Albany, Indiana, United States
Medical Associates Clinic, P.C.
Dubuque, Iowa, United States
Paducah Retinal Center
Paducah, Kentucky, United States
Maine Vitreoretinal Consultants
Bangor, Maine, United States
Elman Retina Group, P.A.
Baltimore, Maryland, United States
Wilmer Ophthalmological Institute at Johns Hopkins
Baltimore, Maryland, United States
Retina Consultants of Delmarva, P.A.
Salisbury, Maryland, United States
Joslin Diabetes Center
Boston, Massachusetts, United States
Ophthalmic Consultants of Boston
Boston, Massachusetts, United States
Retina Center, Pa
Minneapolis, Minnesota, United States
University of Minnesota
Minneapolis, Minnesota, United States
Eyesight Ophthalmic Services, Pa
Portsmouth, New Hampshire, United States
the New York Eye and Ear Infirmary/faculty Eye Practice
New York, New York, United States
Retina-Vitreous Surgeons of Central New York, Pc
Syracuse, New York, United States
University of North Carolina, Dept of Ophthalmology
Chapel Hill, North Carolina, United States
Charlotte Eye, Ear, Nose and Throat Assoc., Pa
Charlotte, North Carolina, United States
Horizon Eye Care, Pa
Charlotte, North Carolina, United States
Wake Forest University Eye Center
Winston-Salem, North Carolina, United States
Case Western Reserve University
Cleveland, Ohio, United States
Osu Eye Physicians and Surgeons, Llc.
Dublin, Ohio, United States
Casey Eye Institute
Portland, Oregon, United States
Retina Northwest, Pc
Portland, Oregon, United States
Penn State College of Medicine
Hershey, Pennsylvania, United States
University of Pennsylvania Scheie Eye Institute
Philadelphia, Pennsylvania, United States
Retina Consultants
Providence, Rhode Island, United States

16 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Ranibizumab →Triamcinolone →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 31 Mar 2007
Primary completion: 31 Oct 2009
Completion: 31 Jul 2010
Last update posted: 26 Aug 2016
Registered enrollment: 333
Registry id: NCT00445003

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.