Clinical trialNCT00445601CompletedPhase 3Interventional

S0337, Gemcitabine After Surgery in Treating Patients With Newly Diagnosed or Recurrent Bladder Cancer

SponsorSWOG Cancer Research NetworkEnrollment406Bladder Cancer

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

RATIONALE: Drugs used in chemotherapy, such as gemcitabine, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving gemcitabine directly into the bladder after surgery may kill more tumor cells. It is not yet known whether giving gemcitabine directly into the bladder is more effective than a placebo in treating bladder cancer. PURPOSE: This randomized phase III trial is studying gemcitabine to see how well it works when given directly into the bladder compared with a placebo after surgery in treating patients with newly diagnosed or recurrent bladder cancer.

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Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

David P. Wood, MD
Beaumont Physician Partners
Study Chair
clinicaltrials.gov ↗
Deepak M. Sahasrabudhe, MD
James P. Wilmot Cancer Center
Study Chair
clinicaltrials.gov ↗
Edward M. Messing, MD, FACS
James P. Wilmot Cancer Center
Study Chair
clinicaltrials.gov ↗
Theresa M. Koppie, MD
Oregon Health and Science University
Study Chair
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

70 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Arkansas Cancer Research Center at University of Arkansas for Medical Sciences
Little Rock, Arkansas, United States
Samuel Oschin Comprehensive Cancer Institute at Cedars-Sinai Medical Center
Los Angeles, California, United States
University of California Davis Cancer Center
Sacramento, California, United States
University of Colorado Cancer Center at Uc Health Sciences Center
Aurora, Colorado, United States
Urology Center of Colorado
Denver, Colorado, United States
Veterans Affairs Medical Center - Denver
Denver, Colorado, United States
St. Joseph Regional Medical Center
Lewiston, Idaho, United States
Cardinal Bernardin Cancer Center at Loyola University Medical Center
Maywood, Illinois, United States
St. Rose Ambulatory and Surgery Center
Great Bend, Kansas, United States
Hays Medical Center
Hays, Kansas, United States
Hutchinson Hospital Corporation
Hutchinson, Kansas, United States
Kansas City Cancer Centers - West
Kansas City, Kansas, United States
Kansas Masonic Cancer Research Institute at the University of Kansas Medical Center
Kansas City, Kansas, United States
Kansas City Cancer Centers - Southwest
Overland Park, Kansas, United States
Mount Carmel Regional Cancer Center
Pittsburg, Kansas, United States
Tammy Walker Cancer Center at Salina Regional Health Center
Salina, Kansas, United States
Kansas City Cancer Center - Shawnee Mission
Shawnee Mission, Kansas, United States
St. Francis Comprehensive Cancer Center
Topeka, Kansas, United States
Feist-Weiller Cancer Center at Louisiana State University Health Sciences
Shreveport, Louisiana, United States
University of Michigan Comprehensive Cancer Center
Ann Arbor, Michigan, United States
Josephine Ford Cancer Center at Henry Ford Hospital
Detroit, Michigan, United States
William Beaumont Hospital - Royal Oak Campus
Royal Oak, Michigan, United States
Kansas City Cancer Centers - North
Kansas City, Missouri, United States
Kansas City Cancer Centers - South
Kansas City, Missouri, United States
Truman Medical Center - Hospital Hill
Kansas City, Missouri, United States
Veterans Affairs Medical Center - Kansas City
Kansas City, Missouri, United States
Kansas City Cancer Centers - East
Lee's Summit, Missouri, United States
Billings Clinic - Downtown
Billings, Montana, United States
Ccop - Montana Cancer Consortium
Billings, Montana, United States
Hematology-Oncology Centers of the Northern Rockies - Billings
Billings, Montana, United States
St. Vincent Healthcare Cancer Care Services
Billings, Montana, United States
Bozeman Deaconess Cancer Center
Bozeman, Montana, United States
St. James Healthcare Cancer Care
Butte, Montana, United States
Great Falls Clinic - Main Facility
Great Falls, Montana, United States
Sletten Cancer Institute at Benefis Healthcare
Great Falls, Montana, United States
Northern Montana Hospital
Havre, Montana, United States
St. Peter'S Hospital
Helena, Montana, United States
Glacier Oncology, Pllc
Kalispell, Montana, United States
Kalispell Medical Oncology at Krmc
Kalispell, Montana, United States
Kalispell Regional Medical Center
Kalispell, Montana, United States

30 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Gemcitabine →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 30 Sept 2007
Primary completion: 30 Jun 2017
Completion: 30 Jun 2017
Last update posted: 18 Jan 2020
Registered enrollment: 406
Registry id: NCT00445601

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.