Clinical trialNCT00448669CompletedPhase 2/PHASE3Interventional

Botswana TDF/FTC Oral HIV Prophylaxis Trial

SponsorCenters for Disease Control and PreventionEnrollment1,219HIV Infections

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This study tested whether taking a pill of tenofovir and emtricitabine (two antiretroviral medicines) was safe for sexually-active young adults in Botswana without HIV infection and whether it reduced their risk of getting an HIV infection.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

Lynn Paxton, MD MPH
Centers for Disease Control and Prevention
Principal Investigator
clinicaltrials.gov ↗
Michael Thigpen, MD MPH
National Institutes of Health (NIH)
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

2 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Botswana

Botusa Hiv Prevention Research Unit
Gaborone, Botswana

United States

Centers for Disease Control and Prevention
Atlanta, Georgia, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

PlaceboTenofovir disoproxil →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 31 Mar 2007
Primary completion: 31 Mar 2011
Completion: 31 Mar 2011
Last update posted: 5 Feb 2020
Registered enrollment: 1,219
Registry id: NCT00448669

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 4 Nov 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.