Clinical trialNCT00465088CompletedPhase 3Interventional

An Open-Label Study to Compare the Lipid Effects of Niacin ER and Simvastatin (NS) to Atorvastatin in Subjects With Hyperlipidemia or Mixed Dyslipidemia (SUPREME)

SponsorAbbottEnrollment199HyperlipidemiaMixed Dyslipidemia

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

To demonstrate that niacin ER and simvastatin (NS) tablets, when compared to atorvastatin (Lipitor®; Pfizer, Inc.), has superior high-density lipoprotein cholesterol (HDL-C) elevating effects at Week 12 in subjects with type II hyperlipidemia or mixed dyslipidemia who are currently off lipid-modifying therapy. This was a prospective, randomized, open-label, blinded endpoint (PROBE) study.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

Roopal Thakkar, MD
Abbott
Study Director
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

46 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Facility name not stated
Anaheim, California, United States
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Huntington Park, California, United States
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Long Beach, California, United States
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Sacramento, California, United States
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Walnut Creek, California, United States
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Brooksville, Florida, United States
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Daytona Beach, Florida, United States
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Gainesville, Florida, United States
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Largo, Florida, United States
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Merritt Island, Florida, United States
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Miami, Florida, United States
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Pembroke Pines, Florida, United States
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Calhoun, Georgia, United States
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Decatur, Georgia, United States
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Dunwoody, Georgia, United States
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Boise, Idaho, United States
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Chicago, Illinois, United States
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Arkansas City, Kansas, United States
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Newton, Kansas, United States
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Shawnee Mission, Kansas, United States
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Topeka, Kansas, United States
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Wichita, Kansas, United States
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Auburn, Maine, United States
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Baltimore, Maryland, United States
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Missoula, Montana, United States
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Charlotte, North Carolina, United States
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High Point, North Carolina, United States
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Canfield, Ohio, United States
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Cincinnati, Ohio, United States
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Dayton, Ohio, United States
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Protland, Oregon, United States
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Chicora, Pennsylvania, United States
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Duncansville, Pennsylvania, United States
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Harleysville, Pennsylvania, United States
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Pittsburgh, Pennsylvania, United States
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Austin, Texas, United States
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Carrollton, Texas, United States
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Dallas, Texas, United States
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Houston, Texas, United States
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San Antonio, Texas, United States

6 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Niacin ER/Simvastatin TabletsAtorvastatin →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 30 Apr 2007
Primary completion: 29 Feb 2008
Completion: —
Last update posted: 13 Jun 2011
Registered enrollment: 199
Registry id: NCT00465088

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 4 Nov 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.