Clinical trialNCT00489411CompletedPhase 3Interventional

Duloxetine in Treating Peripheral Neuropathy Caused by Chemotherapy in Patients With Cancer

SponsorAlliance for Clinical Trials in OncologyEnrollment231NeurotoxicityPainPeripheral NeuropathyUnspecified Adult Solid Tumor, Protocol Specific

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

RATIONALE: Duloxetine may lessen peripheral neuropathy caused by chemotherapy. It is not yet known whether duloxetine is more effective than a placebo in treating peripheral neuropathy caused by chemotherapy. PURPOSE: This randomized phase III trial is studying duloxetine to see how well it works compared with a placebo in treating peripheral neuropathy caused by chemotherapy in patients with cancer.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Ellen L. Smith, PhD, ARNP, AOCN
University of Michigan
Study Chair
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A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

475 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Kaiser Permanente - Deer Valley
Antioch, California, United States
Alta Bates Summit Comprehensive Cancer Center
Berkeley, California, United States
Peninsula Medical Center
Burlingame, California, United States
East Bay Radiation Oncology Center
Castro Valley, California, United States
Valley Medical Oncology Consultants - Castro Valley
Castro Valley, California, United States
Cancer Care Center at John Muir Health - Concord Campus
Concord, California, United States
Kaiser Permanente - Fremont
Fremont, California, United States
Valley Medical Oncology
Fremont, California, United States
Glendale Memorial Hospital Comprehensive Cancer Center
Glendale, California, United States
Kaiser Permanente Medical Center - Hayward
Hayward, California, United States
Rebecca and John Moores Ucsd Cancer Center
La Jolla, California, United States
Usc/norris Comprehensive Cancer Center and Hospital
Los Angeles, California, United States
Contra Costa Regional Medical Center
Martinez, California, United States
Camino Medical Group - Treatment Center
Mountain View, California, United States
El Camino Hospital Cancer Center
Mountain View, California, United States
Alta Bates Summit Medical Center - Summit Campus
Oakland, California, United States
Bay Area Breast Surgeons, Incorporated
Oakland, California, United States
Ccop - Bay Area Tumor Institute
Oakland, California, United States
Highland General Hospital
Oakland, California, United States
Kaiser Permanente - Division of Research - Oakland
Oakland, California, United States
Kaiser Permanente Medical Center - Oakland
Oakland, California, United States
Larry G Strieff Md Medical Corporation
Oakland, California, United States
Tom K Lee, Incorporated
Oakland, California, United States
Palo Alto Medical Foundation
Palo Alto, California, United States
Facility name not stated
Pismo Beach, California, United States
Kaiser Permanente Medical Center - Rancho Cordova
Rancho Cardova, California, United States
Kaiser Permanente Medical Center - Redwood City
Redwood City, California, United States
Kaiser Permanente Medical Center - Richmond
Richmond, California, United States
Rohnert Park Cancer Center
Rohnert Park, California, United States
Kaiser Permanente Medical Center - Roseville
Roseville, California, United States
Sutter Cancer Center at Roseville Medical Center
Roseville, California, United States
Kaiser Permanente Medical Center - Sacramento
Sacramento, California, United States
South Sacramento Cancer Center
Sacramento, California, United States
South Sacramento Kaiser-Permanente Medical Center
Sacramento, California, United States
Sutter Cancer Center
Sacramento, California, United States
Kaiser Permanente Medical Office -Vandever Medical Office
San Diego, California, United States
California Pacific Medical Center - California Campus
San Francisco, California, United States
Kaiser Permanente Medical Center - San Francisco Geary Campus
San Francisco, California, United States
Kaiser Permanente Medical Center - Santa Teresa
San Jose, California, United States
Doctors Medical Center - San Pablo Campus
San Pablo, California, United States

435 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Duloxetine →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 30 Apr 2008
Primary completion: 31 Jan 2012
Completion: 31 Mar 2013
Last update posted: 26 Apr 2017
Registered enrollment: 231
Registry id: NCT00489411

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.