Clinical trialNCT00494507CompletedPhase 3Interventional

Hyper- and Hypokalemic Periodic Paralysis Study

SponsorUniversity of RochesterEnrollment71Hyperkalemic Periodic ParalysisHypokalemic Periodic Paralysis

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The purpose of this study is to compare Dichlorphenamide with placebo (an inactive substance) for prevention of episodes and for improvement of strength in hyperkalemic (HYP) and hypokalemic (HOP) periodic paralysis. This study will also look at the long-term effects of Dichlorphenamide in periodic paralysis.

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Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Michael McDermott, Ph.D.
Biostatistician, University of Rochester
clinicaltrials.gov ↗
Rabi Tawil, M.D.
Co-Principal Investigator, University of Rochester
Principal Investigator
clinicaltrials.gov ↗
Robert C. Griggs, M.D.
University of Rochester
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

12 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Italy

University of Milan
San Donato, Milan, Italy

United Kingdom

Institute of Neurology-Queen'S Square
London, United Kingdom

United States

Ucla Neurology
Los Angeles, California, United States
University of California-San Francisco
San Francisco, California, United States
University of Kansas Medical Center
Kansas City, Kansas, United States
Brigham & Women'S Hospital
Boston, Massachusetts, United States
Mayo Clinic
Rochester, Minnesota, United States
Washington University School of Medicine
St Louis, Missouri, United States
Columbia University Medical Center
New York, New York, United States
University of Rochester
Rochester, New York, United States
Ohio State University
Columbus, Ohio, United States
University of Texas Southwestern-Dallas
Dallas, Texas, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Dichlorphenamide →Placebo

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 30 Jun 2007
Primary completion: 30 Apr 2013
Completion: 31 May 2013
Last update posted: 14 Jun 2017
Registered enrollment: 71
Registry id: NCT00494507

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.