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Clinical trialNCT00499902TerminatedPhase 2Interventional

Phase 2 Proof-of-Concept Study of the Safety and Efficacy of Alfimeprase to Rapidly Open Arteries and Restore Brain Function Following a Stroke

SponsorARCA Biopharma, Inc.Enrollment7Acute Ischemic Stroke
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The purpose of this study is to identify a safe and effective bolus dose of intra-arterial/intra-thrombus alfimeprase in acute ischemic stroke (AIS) 3 to 9 hours from symptom onset.

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

22 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Canada
  • University of Calgary, Foothills Medical Centre

    Calgary, Alberta, Canada

  • Vancouver General Hospital

    Vancouver, British Columbia, Canada

  • Trilium Health Center

    Mississauga, Ontario, Canada

  • University Health Network Toronto

    Toronto, Ontario, Canada

  • Montreal Neurological Institute

    Montreal, Quebec, Canada

United States
  • Ucla Medical Center

    Los Angeles, California, United States

  • Northwestern Medical Center

    Chicago, Illinois, United States

  • Ruan Neurology & Clinical Research Center

    Des Moines, Iowa, United States

  • University of Iowa Hospital

    Iowa City, Iowa, United States

  • University of Iowa Hospital

    Iowa City, Iowa, United States

  • University of Kansas School of Medicine, Via Christi Regional Medical Center

    Wichita, Kansas, United States

  • Norton Hospital

    Louisville, Kentucky, United States

  • Michigan State University, Sparrow Hospital

    Lansing, Michigan, United States

  • Albany Medical Center Hospital

    Albany, New York, United States

  • Kalieda Health, Mfh

    Buffalo, New York, United States

  • Columbia Presbyterian Medical Center

    New York, New York, United States

  • University of Cincinnati

    Cincinnati, Ohio, United States

  • Riverside Methodist Hospital

    Columbus, Ohio, United States

  • Oregon Stroke Center

    Portland, Oregon, United States

  • University of Pittsburg Medical Center

    Pittsburgh, Pennsylvania, United States

  • Baylor College of Medicine

    Houston, Texas, United States

  • St. Luke'S Medical Center

    Milwaukee, Wisconsin, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Alfimeprase
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
30 Jun 2007
Primary completion
31 May 2008
Completion
31 May 2008
Last update posted
24 Apr 2008
Registered enrollment
7
Registry id
NCT00499902

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.