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Clinical trialNCT00531466TerminatedPhase 2Interventional

Safety and Preliminary Effectiveness of AV650 in Patients With Spasticity Due to Spinal Cord Injury

SponsorAvigenEnrollment120Muscle Spasticity
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

A drug called AV650 (tolperisone HCl) will be given to patients who have spasticity following a spinal cord injury. This study has three purposes: 1. To determine whether AV650 is safe for patients with spinal cord injury; 2. To assess what the body does with AV650 once it is ingested; and, 3. To gather some early evidence as to whether AV650 is effective in treating spasticity in patients with spinal cord injury.
clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

10 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Canada
  • Rehabilitation Hospital Health Sciences Centre

    Winnipeg, Quebec, Canada

United States
  • Southern California Clinical Research, Inc.

    Pasadena, California, United States

  • University of Miami Miller School of Medicine

    Miami, Florida, United States

  • Shepherd Center, Inc.

    Atlanta, Georgia, United States

  • Internal Center for Spinal Cord Injury Kennedy Kreiger Institute

    Baltimore, Maryland, United States

  • Kernan Orthopaedics & Rehab. Hospital

    Baltimore, Maryland, United States

  • Kessler Institute for Rehab.

    West Orange, New Jersey, United States

  • Carolinas Rehabilitation

    Charlotte, North Carolina, United States

  • Jefferson Medical College of Thomas Jefferson University

    Philadelphia, Pennsylvania, United States

  • Hunter Holmes Mcguire Veterans Affairs Medical Center

    Richmond, Virginia, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

PlaceboTolperisone HCl
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
30 Sept 2007
Primary completion
30 Nov 2008
Completion
30 Nov 2008
Last update posted
4 Nov 2008
Registered enrollment
120
Registry id
NCT00531466
clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 11 Nov 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.