Clinical trialNCT00533949CompletedPhase 3Interventional

High-Dose or Standard-Dose Radiation Therapy and Chemotherapy With or Without Cetuximab in Treating Patients With Newly Diagnosed Stage III Non-Small Cell Lung Cancer That Cannot Be Removed by Surgery

SponsorRadiation Therapy Oncology GroupEnrollment544Lung CancerRadiation Toxicity

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs used in chemotherapy, such as paclitaxel, carboplatin work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Monoclonal antibodies, such as cetuximab can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. It is not yet known whether high-dose radiation therapy is more effective than standard-dose radiation therapy when given together with combination chemotherapy with or without cetuximab in treating patients with non-small cell lung cancer. PURPOSE: This randomized phase III trial is studying high-dose or standard-dose radiation therapy given together with chemotherapy with or without cetuximab to see how well they work in treating patients with newly diagnosed stage III non-small cell lung cancer that cannot be removed by surgery.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Alex A. Adjei, MD, PhD
Roswell Park Cancer Institute
Study Chair
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Arthur William Blackstock, MD
Wake Forest University Health Sciences
Study Chair
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Benjamin Movsas, MD
Henry Ford Hospital
Study Chair
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George Blumenschein, MD
M.D. Anderson Cancer Center
Study Chair
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Gregory A. Masters, MD
CCOP - Christiana Care Health Services
Study Chair
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Hak Choy, MD
Simmons Cancer Center
Study Chair
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Jeff Sloan, PhD, HSR
Mayo Clinic
Study Chair
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Jeffrey A. Bogart, MD
State University of New York - Upstate Medical University
Study Chair
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Jeffrey Bradley, MD
Mallinckrodt Institute of Radiology at Washington University Medical Center
Principal Investigator
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Joe Y. Chang, MD PhD
M.D. Anderson Cancer Center
Study Chair
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Joseph O. Deasy, PhD
Memorial Sloan Kettering Cancer Center
Study Chair
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Ken Forster, PhD
H. Lee Moffitt Cancer Center
Study Chair
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Mark A. Socinski, MD
UNC Lineberger Comprehensive Cancer Center
Study ChairKOL profile →
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Mark Dobelbower, MD PhD
University of Alabama Medical Center
Study Chair
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Ritsuko Komaki, MD
M.D. Anderson Cancer Center
Study Chair
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Steven E. Schild, MD
Mayo Clinic
Study Chair
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Tien Hoang, MD
University of Wisconsin, Madison
Study Chair
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A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

213 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Canada

Tom Baker Cancer Centre - Calgary
Calgary, Alberta, Canada
Cancercare Manitoba
Winnipeg, Manitoba, Canada
Princess Margaret Hospital
Toronto, Ontario, Canada
Hopital Notre-Dame Du Chum
Montreal, Quebec, Canada
Allan Blair Cancer Centre at Pasqua Hospital
Regina, Saskatchewan, Canada
Saskatoon Cancer Centre at the University of Saskatchewan
Saskatoon, Saskatchewan, Canada

United States

Uab Comprehensive Cancer Center
Birmingham, Alabama, United States
Mayo Clinic Scottsdale
Scottsdale, Arizona, United States
Arizona Oncology - Tucson
Tucson, Arizona, United States
Mercy Cancer Center at Mercy San Juan Medical Center
Carmichael, California, United States
Enloe Cancer Center at Enloe Medical Center
Chico, California, United States
Cancer Care Center at John Muir Health - Concord Campus
Concord, California, United States
Saint Agnes Cancer Center at Saint Agnes Medical Center
Fresno, California, United States
Rebecca and John Moores Ucsd Cancer Center
La Jolla, California, United States
Memorial Medical Center
Modesto, California, United States
St. Joseph Hospital Regional Cancer Center - Orange
Orange, California, United States
Feather River Hospital Cancer Center
Paradise, California, United States
Radiation Oncology Center - Roseville
Roseville, California, United States
Radiological Associates of Sacramento Medical Group, Incorporated
Sacramento, California, United States
University of California Davis Cancer Center
Sacramento, California, United States
Ucsf Helen Diller Family Comprehensive Cancer Center
San Francisco, California, United States
Saint Helena Hospital
St. Helena, California, United States
Stanford Cancer Center
Stanford, California, United States
Penrose Cancer Center at Penrose Hospital
Colorado Springs, Colorado, United States
Swedish Medical Center
Englewood, Colorado, United States
Poudre Valley Radiation Oncology
Fort Collins, Colorado, United States
North Suburban Medical Center
Thornton, Colorado, United States
Ccop - Christiana Care Health Services
Newark, Delaware, United States
Washington Cancer Institute at Washington Hospital Center
Washington D.C., District of Columbia, United States
Broward General Medical Center Cancer Center
Fort Lauderdale, Florida, United States
University of Florida Shands Cancer Center
Gainesville, Florida, United States
Memorial Cancer Institute at Memorial Regional Hospital
Hollywood, Florida, United States
Baptist Cancer Institute - Jacksonville
Jacksonville, Florida, United States
Baptist Medical Center South
Jacksonville, Florida, United States
Integrated Community Oncology Network at Southside Cancer Center
Jacksonville, Florida, United States
Mayo Clinic - Jacksonville
Jacksonville, Florida, United States
Integrated Community Oncology Network
Jacksonville Beach, Florida, United States
Ella Milbank Foshay Cancer Center at Jupiter Medical Center
Jupiter, Florida, United States
Baptist-South Miami Regional Cancer Program
Miami, Florida, United States
Ccop - Mount Sinai Medical Center
Miami Beach, Florida, United States

173 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Carboplatin →Cetuximab →Paclitaxel →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 30 Nov 2007
Primary completion: 30 Jun 2013
Completion: 20 May 2022
Last update posted: 21 Jun 2022
Registered enrollment: 544
Registry id: NCT00533949

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.