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Clinical trialNCT00536016CompletedPhase 1Interventional

A Phase 1 Safety Study of Single and Repeated Doses of JSM6427 (Intravitreal Injection) to Treat AMD

SponsorJerini OphthalmicEnrollment36Macular Degeneration
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The purpose of this study is to determine the way and rate that the study medication, JSM6427 a potent, highly specific integrin α5β1-antagonist is absorbed, broken-down and eliminated from the body when it is given as a single dosage strength by injection into the eye. Repeated dosages will also be given to determine the highest safe dose.
clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

9 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States
  • Retina Vitreous Associates Medical Group

    Beverly Hills, California, United States

  • Ophthalmic Consultants of Boston

    Boston, Massachusetts, United States

  • William Beaumont Research Institute

    Royal Oak, Michigan, United States

  • Dean Mcgee Eye Institute

    Oklahoma City, Oklahoma, United States

  • Palmetto Retina Center

    West Columbia, South Carolina, United States

  • Black Hills Regional Eye Institute

    Rapid City, South Dakota, United States

  • Retina Research Institute of Texas

    Abilene, Texas, United States

  • Vitreoretinal Consultants

    Houston, Texas, United States

  • Valley Retina Institute

    McAllen, Texas, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

JSM6427
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
30 Sept 2007
Primary completion
31 Dec 2008
Completion
31 Dec 2009
Last update posted
21 Sept 2010
Registered enrollment
36
Registry id
NCT00536016
clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.