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Clinical trialNCT00550459CompletedPhase 3Interventional

Effects of Titrated Oral Tolvaptan 15-60 mg Once Daily (QD) on Cognitive and Neurological Function in Elderly Hyponatremic Patients

SponsorOtsuka Pharmaceutical Development & Commercialization, Inc.Enrollment57Hyponatremia
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

Demonstrate an improvement in the composite scores of validated neurocognitive tests in elderly subjects with chronic sub-clinical (i.e., asymptomatic) hyponatremia.
clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

  • Joseph Verbalis, MD

    Georgetown University, Washington, DC, 20007 USA

    Principal Investigator
    clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

12 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States
  • Sarah. S. Olelewe, Md

    Hawthorne, California, United States

  • Progressive Clinical Research

    Vista, California, United States

  • Pikes Peak Cardiology

    Colorado Springs, Colorado, United States

  • Innovative Research of West Fl

    Largo, Florida, United States

  • Coastal Nephrology Assoc. Research Center

    Punta Gorda, Florida, United States

  • Rockdale Medical Research Associates

    Conyers, Georgia, United States

  • Otis Barnum, Do

    Natchitoches, Louisiana, United States

  • Lillestol Research, Llc

    Fargo, North Dakota, United States

  • Carolina Research Associates

    Columbia, South Carolina, United States

  • Wayne O. Wells, Md

    Lebanon, Tennessee, United States

  • Memorial Clinical Associates

    Houston, Texas, United States

  • Mitchell Rosner, Md

    Charlottesville, Virginia, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

PlaceboTolvaptan →
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
31 Aug 2007
Primary completion
28 Feb 2009
Completion
31 Mar 2009
Last update posted
28 Apr 2011
Registered enrollment
57
Registry id
NCT00550459
clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 30 Jul 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.