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Clinical trialNCT00571272SuspendedObservational

Longitudinal Study of Genetic Causes of Intrahepatic Cholestasis (LOGIC)

SponsorArbor Research Collaborative for HealthEnrollment1,675Alagille SyndromeAlpha 1-Antitrypsin DeficiencyLiver Diseases
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

Cholestasis is a condition in which bile is not properly transported from the liver to the small intestine. Cholestasis can be caused by an array of childhood diseases, including the genetic diseases Alagille syndrome (ALGS), alpha-1 antitrypsin (a-1AT) deficiency, bile acid synthesis and metabolism defects, and progressive familial intrahepatic cholestasis (PFIC) or benign recurrent intrahepatic cholestasis(BRIC). This study will investigate the natural history and progression of the four previously mentioned cholestatic liver diseases to provide a better understanding of the causes and effects of the diseases.
clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

17 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Canada
  • the Hospital for Sick Children

    Toronto, Ontario, Canada

United States
  • Children'S Hospital of Los Angeles

    Los Angeles, California, United States

  • University of California at San Francisco (ucsf)

    San Francisco, California, United States

  • Children'S Hospital Colorado

    Aurora, Colorado, United States

  • Children'S Healthcare of Atlanta - Emory University

    Atlanta, Georgia, United States

  • Ann & Robert H. Lurie Children'S Hospital of Chicago

    Chicago, Illinois, United States

  • Riley Hospital for Children

    Indianapolis, Indiana, United States

  • Johns Hopkins University Hospital

    Baltimore, Maryland, United States

  • St. Louis University - Cardinal Glennon Children'S Medical Center

    St Louis, Missouri, United States

  • Washington University School of Medicine/st. Louis Children'S Hospital

    St Louis, Missouri, United States

  • Mount Sinai School of Medicine

    New York, New York, United States

  • Cincinnati'S Children'S Memorial Hospital

    Cincinnati, Ohio, United States

  • Children'S Hospital of Philadelphia

    Philadelphia, Pennsylvania, United States

  • Upmc Children'S Hospital of Pittsburgh

    Pittsburgh, Pennsylvania, United States

  • Baylor School of Medicine

    Houston, Texas, United States

  • University of Utah

    Salt Lake City, Utah, United States

  • Seattle Children'S Hospital

    Seattle, Washington, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

No drug or biological interventions are in our data for this study. It may test a procedure, device or behavioral intervention, or the intervention list isn't in our current snapshot. See the registry record ↗. Why? →

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
30 Nov 2007
Primary completion
31 May 2029
Completion
31 May 2029
Last update posted
4 Jun 2026
Registered enrollment
1,675
Registry id
NCT00571272
clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.