Clinical trialNCT00582010CompletedPhase 2/PHASE3Interventional

Study to Evaluate if Inhaled Nitric Oxide Improves Liver Function After Transplantation

SponsorUniversity of Alabama at BirminghamEnrollment80Liver InjuryReperfusion Injury

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This blinded, placebo-controlled study will administer inhaled nitric oxide to patients undergoing liver transplantation. The purpose of the study is to test if inhaled nitric oxide prevents liver injury associated with the restoration of blood flow. The premise of the current study is provided by previous studies which document a protective effect of inhaled nitric oxide in this clinical setting.

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Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

Blair Smith, MD
University of Alabama at Birmingham
Study Director
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Clark Cross, MD
University of Alabama at Birmingham
Study Chair
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Devin E Eckhoff, MD
University of Alabama at Birmingham
Principal Investigator
clinicaltrials.gov ↗
John D Lang, MD
University of Washington
Principal Investigator
clinicaltrials.gov ↗
John S Bynon, MD
University of Alabama at Birmingham
Study Director
clinicaltrials.gov ↗
Keith A Jones, MD
University of Alabama at Birmingham
Principal Investigator
clinicaltrials.gov ↗
Luc Frenette, MD
University of Alabama at Birmingham
Study Director
clinicaltrials.gov ↗
Rakesh P Patel, PhD
University of Alabama at Birmingham
Principal Investigator
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A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

2 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

University of Alabama at Birmingham
Birmingham, Alabama, United States
University of Washington
Seattle, Washington, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Inhaled nitric oxideNitrogen gas

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 30 Apr 2008
Primary completion: 31 Mar 2009
Completion: 31 Oct 2012
Last update posted: 6 Nov 2014
Registered enrollment: 80
Registry id: NCT00582010

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Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 11 Nov 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.