Clinical trialNCT00593450CompletedPhase 3Interventional

Comparison of Age-related Macular Degeneration Treatments Trials: Lucentis-Avastin Trial

SponsorUniversity of PennsylvaniaEnrollment1,208Age Related Macular Degeneration

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The purpose of the study is to evaluate the relative efficacy and safety of treatment of neovascular AMD with Lucentis on a fixed schedule, Avastin on a fixed schedule, Lucentis on a variable schedule, and Avastin on a variable schedule. A five year follow-up visit is being conducted in 2014 to gather information on long term outcomes.

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Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

Daniel F Martin, MD
The Cleveland Clinic
Study Chair
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Glenn Jaffe,, MD
Director of OCT Reading Center, Duke University
Study DirectorKOL profile →
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Juan E Grunwald, MD
Principal Investigator of Photography Reading Center, Universisty of Pennsylvania
Principal Investigator
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Maureen G Maguire, PhD
Director of Coordinating Center, University of Pennsylvania
Study Director
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Stuart L Fine, MD
Study Vice-Chair, University of Pennsylvania
Study ChairKOL profile →
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

59 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Retina Consultants of Arizona
Mesa, Arizona, United States
Retinal Consultants of Arizona
Phoenix, Arizona, United States
Retina Associates Southwest, P.C.
Tucson, Arizona, United States
California Retina Consultants
Bakersfield, California, United States
Retina-Vitreous Associates Medical Group
Beverly Hills, California, United States
Retinal Consultants Medical Group, Inc.
Sacramento, California, United States
University of California-Davis Medical Center
Sacramento, California, United States
West Coast Retina Medical Group, Inc.
San Francisco, California, United States
California Retinal Consultants
Santa Barbara, California, United States
West Coast Retina Medical Group, Inc.
Walnut Creek, California, United States
Colorado Retina Associates
Denver, Colorado, United States
Retina Group of Florida
Fort Lauderdale, Florida, United States
National Ophthalmic Research Institute
Fort Myers, Florida, United States
Emory Eye Center
Atlanta, Georgia, United States
Illinois Retina Associates
Flossmoor, Illinois, United States
Ingalls Memorial Hospital/illinois Retina Associates
Harvey, Illinois, United States
Illinois Retina Associates
Joliet, Illinois, United States
Midwest Eye Institute
Indianapolis, Indiana, United States
University of Iowa Hospitals and Clinics
Iowa City, Iowa, United States
Retina Associates of Kentucky
Lexington, Kentucky, United States
University of Louisville School of Medicine
Louisville, Kentucky, United States
Elman Retina Group, P.A.
Baltimore, Maryland, United States
the Retina Group of Washington
Chevy Chase, Maryland, United States
Retina Specialists
Towson, Maryland, United States
Harvard Vanguard Medical Associates
Boston, Massachusetts, United States
Massachusetts Eye & Ear Infirmary
Boston, Massachusetts, United States
Opthalmic Consultants of Boston
Boston, Massachusetts, United States
Vision Research Foundation/associated Retinal Consultants, P.C.
Grand Rapids, Michigan, United States
Vision Research Foundation/associated Retinal Consultants, P.C.
Royal Oak, Michigan, United States
Vision Research Foundation/associated Retinal Consultants. P.C.
Traverse City, Michigan, United States
Vitreoretinal Surgery
Edina, Minnesota, United States
Mayo Clinic
Rochester, Minnesota, United States
Barnes Retina Institute
St Louis, Missouri, United States
Retina Vitreous Center, Pa
New Brunswick, New Jersey, United States
Retina Vitreous Center, Pa
Toms River, New Jersey, United States
Long Island Vitreoretinal Consultants
Great Neck, New York, United States
Long Island Vitreoretinal Consultants
Riverhead, New York, United States
University of North Carolina at Chapel Hill
Chapel Hill, North Carolina, United States
Charlotte Eye, Ear, Nose & Throat Associates
Charlotte, North Carolina, United States
Duke University Eye Center
Durham, North Carolina, United States

19 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Bevacizumab →Ranibizumab →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 29 Feb 2008
Primary completion: 31 Dec 2010
Completion: 30 Apr 2015
Last update posted: 21 Aug 2017
Registered enrollment: 1,208
Registry id: NCT00593450

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.