Clinical trialNCT00600106CompletedInterventional

Data Analyses for Ancillary WISE Femhrt Hormone Replacement Study

SponsorCedars-Sinai Medical CenterEnrollment37Myocardial Ischemia

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The goal of the main trial was to evaluate the effect of low dose hormone replacement therapy with 1 mg norethindrone/10mcg ethinyl estradiol in postmenopausal women with a history of chest discomfort, myocardial ischemia and no obstructive CAD. For the purposes of this study as a core lab coordinating center, the investigators will be performing P31 MRS core lab analyses; hormone core lab analyses; lipid core lab analyses; glucose, insulin and HOMA core lab analyses; exercise stress test/Holter monitor core lab analyses; brachial artery reactivity test core lab analyses; full study data analyses for manuscript preparation and the writing and submission and publication of manuscript. The main trial duration: December 1999 - May 2003. The ancillary data analysis project duration: April 2006 - March 2010.

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Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

C. Noel Bairey Merz, MD
Cedars-Sinai Medical Center
Study Chair
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Carl Pepine, MD
University of Florida
Principal InvestigatorKOL profile →
clinicaltrials.gov ↗
Connie McLaughlin, PharmD
Parke-Davis
Study Director
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George Sopko, MD
National Institute of Health (WISE Project Officer)
Study Director
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James Symons, PhD
Parke-Davis
Study Director
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Nathaniel Reichek, MD
Allegheny University of the Health Sciences
Principal Investigator
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Robert B Weiss, MD
Johns Hopkins University
Principal Investigator
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Sheryl Kelsey, PhD
University of Pittsburgh
Principal Investigator
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Steve Reis, MD
University of Pittsburgh
Principal Investigator
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Vijay Misra, MD
University of Alabama at Birmingham
Principal Investigator
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William Rogers, MD
University of Alabama at Birmingham
Principal Investigator
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A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

1 registered facility, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Cedars-Sinai Women'S Heart Center, 8631 W. 3rd St, Suite 740
Los Angeles, California, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

1/10 NA/EEPlacebo

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 31 Dec 1999
Primary completion: 31 May 2003
Completion: 31 Mar 2010
Last update posted: 24 Apr 2019
Registered enrollment: 37
Registry id: NCT00600106

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 4 Nov 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.