Clinical trialNCT00608764Active, not recruitingObservational

Examining the Genetic Factors That May Cause Chronic Obstructive Pulmonary Disease (COPD)

SponsorBrigham and Women's HospitalEnrollment10,718Bronchitis, ChronicEmphysemaPulmonary Disease, Chronic Obstructive

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

Chronic obstructive pulmonary disease (COPD) is a long-term lung disease that is often caused by cigarette smoking. The purpose of this study is to evaluate whether certain genetic factors predispose some smokers to develop COPD more than others.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Edwin K. Silverman, MD, PhD
Brigham and Women's Hospital
Principal InvestigatorKOL profile →
clinicaltrials.gov ↗
James D. Crapo, MD
National Jewish Health
Principal InvestigatorKOL profile →
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

20 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

University of Alabama at Birmingham
Birmingham, Alabama, United States
University of California at San Diego
San Diego, California, United States
Los Angeles Biomedical Research Institute
Torrance, California, United States
National Jewish Health
Denver, Colorado, United States
Morehouse School of Medicine
Atlanta, Georgia, United States
University of Iowa
Iowa City, Iowa, United States
Johns Hopkins University
Baltimore, Maryland, United States
Brigham and Women'S Hospital
Boston, Massachusetts, United States
Reliant Medical Group
Worcester, Massachusetts, United States
Ann Arbor Va Medical Center
Ann Arbor, Michigan, United States
University of Michigan
Ann Arbor, Michigan, United States
Healthpartners Research Foundation
Minneapolis, Minnesota, United States
Minneapolis Va Medical Center
Minneapolis, Minnesota, United States
University of Minnesota
Minneapolis, Minnesota, United States
Columbia University Medical Center
New York, New York, United States
Duke University
Durham, North Carolina, United States
Temple University
Philadelphia, Pennsylvania, United States
University of Pittsburgh
Pittsburgh, Pennsylvania, United States
Baylor College of Medicine
Houston, Texas, United States
University of Texas Health Sciences Center at San Antonio
San Antonio, Texas, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

No drug or biological interventions are in our data for this study. It may test a procedure, device or behavioral intervention, or the intervention list isn't in our current snapshot. See the registry record ↗. Why? →

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 30 Nov 2007
Primary completion: 31 Aug 2028
Completion: 31 Aug 2028
Last update posted: 17 Sept 2025
Registered enrollment: 10,718
Registry id: NCT00608764

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.