Clinical trialNCT00627393CompletedPhase 3Interventional

Safety and Effectiveness of Granulocyte Transfusions in Resolving Infection in People With Neutropenia (The RING Study)

SponsorCarelon ResearchEnrollment114InfectionNeutropenia

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

Neutropenia, a condition characterized by an abnormally low number of infection-fighting white blood cells called neutrophils, commonly develops in people who have undergone chemotherapy or hematopoietic stem cell (HSC) transplantation. The severely reduced immunity of those with neutropenia can put them at risk of entry of life-threatening infections, making the implementation of treatments that increase white blood cell numbers important. Several studies have shown that the transfusion of donor granulocytes, a type of white blood cell that includes neutrophils, is effective in promoting the recovery of adequate numbers of granulocytes. However, granulocyte transfusions can cause side effects, and it is not known whether the success of the therapy outweighs the health risks of the side effects. This study will evaluate the safety and effectiveness of granulocyte transfusions in treating people with a bacterial or fungal infection during neutropenia.

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Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

Bruce Sachais, MD, PHD
University of Pennsylvania
Principal Investigator
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Cassandra Josephson, MD
Emory University
Principal Investigator
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Darrell Triulzi, MD
University of Pittsburgh Presbyterian and Shadyside/Children's Hospital Pittsburgh
Principal Investigator
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David Friedman, MD
Children's Hospital of Philadelphia
Principal Investigator
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Eliot Williams, MD
University of Wisconsin, Madison
Principal Investigator
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Ellis Neufeld, MD
Children's Hospital Boston/Brigham and Women's Hospital
Principal Investigator
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James Bussel, MD
Weill Medical College, Cornell University
Principal Investigator
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James George, MD
University of Oklahoma
Principal Investigator
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Jan McFarland, MD
Froedtert Hospital
Principal Investigator
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Jeffrey McCullough, MD
University of Minnesota
Principal Investigator
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Paul Ness, MD
Johns Hopkins University
Principal Investigator
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Ronald Strauss, MD
University of Iowa
Principal Investigator
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Sherrill Slichter, MD
University of Washington
Principal Investigator
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Susan F. Assmann, PhD
Carelon Research
Principal Investigator
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Thomas Price, MD
Bloodworks
Study Chair
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A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

13 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

University of Iowa Hospitals and Clinics
Iowa City, Iowa, United States
Johns Hopkins Hospital
Baltimore, Maryland, United States
Children'S Hospital Boston
Boston, Massachusetts, United States
University of Minnesota
Minneapolis, Minnesota, United States
Weill Medical College, Cornell University
New York, New York, United States
Montefiore Medical Center
The Bronx, New York, United States
University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma, United States
Chlidren'S Hospital of Philadelphia
Philadelphia, Pennsylvania, United States
University of Pennsylvania
Philadelphia, Pennsylvania, United States
University of Pittsburgh Presbyterian and Shadyside
Pittsburgh, Pennsylvania, United States
University of Washington Medical Center
Seattle, Washington, United States
University of Wisconsin at Madison
Madison, Wisconsin, United States
Froedtert Memorial Lutheran Hospital
Milwaukee, Wisconsin, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

G-CSF/dexamethasoneGranulocyte transfusionsStandard antimicrobial therapy

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 30 Apr 2008
Primary completion: 30 Apr 2013
Completion: 31 May 2013
Last update posted: 17 Apr 2015
Registered enrollment: 114
Registry id: NCT00627393

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 4 Nov 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.