Clinical trialNCT00630227CompletedPhase 2Interventional

Biologic Lung Volume Reduction (BLVR) Phase 2 Homogeneous Study

SponsorAeris TherapeuticsEnrollment33Homogeneous Emphysema

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The purpose of the study is to evaluate the efficacy and safety of the 20 mL BLVR System in patients with homogeneous emphysema. Patients with upper lobe predominant emphysema initially screened for earlier Phase 2 studies but not enrolled before study enrollment closed are also eligible for participation.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

Geoffrey McLennan, MD
University of Iowa Hospitals & Clinics, Iowa City, IA
Principal Investigator
clinicaltrials.gov ↗
Gerard Criner, MD
Temple University Lung Center, Philadelphia, PA
Principal InvestigatorKOL profile →
clinicaltrials.gov ↗
Mark Dransfield, MD
University of Alabama, Birmingham, AL
Principal Investigator
clinicaltrials.gov ↗
Mark Gotfried, MD
Pulmonary Associates, Phoenix, AZ
Principal InvestigatorKOL profile →
clinicaltrials.gov ↗
Mark Krasna, MD
St Josephs Medical Center, Towson, MD
Principal Investigator
clinicaltrials.gov ↗
Sanjiv Tewari, MD
Akron Medical Center, Akron, OH
Principal Investigator
clinicaltrials.gov ↗
Thomas Gildea, MD
Cleveland Clinic, Cleveland, OH
Principal InvestigatorKOL profile →
clinicaltrials.gov ↗
William Leeds, DO
Veritas Clinical Specialties, Topeka, KS
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

8 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

University of Alabama
Birmingham, Alabama, United States
Pulmonary Associates
Phoenix, Arizona, United States
University of Iowa Hospitals & Clinics
Iowa City, Iowa, United States
Veritas Clinical Specialties
Topeka, Kansas, United States
St Josephs Medical Center
Towson, Maryland, United States
Akron Medical Center
Akron, Ohio, United States
Cleveland Clinic Foundation, Pulmonary Allergy & Critical Care Medicine
Cleveland, Ohio, United States
Temple University Lung Center
Philadelphia, Pennsylvania, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Biologic Lung Volume Reduction

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 29 Feb 2008
Primary completion: 31 Dec 2009
Completion: 31 Dec 2009
Last update posted: 24 Oct 2011
Registered enrollment: 33
Registry id: NCT00630227

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.