Clinical trialNCT00637494TerminatedPhase 3Interventional

A Study of Mifepristone vs. Placebo in the Treatment of Patients With Major Depression With Psychotic Features

SponsorCorcept TherapeuticsEnrollment292PsychosisPsychotic DepressionSevere Major Depression With Psychotic Features

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

Approximately 450 patients will be randomized to receive mifepristone or placebo for 7 days followed by antidepressant. The purpose is to compare the efficacy of mifepristone followed by antidepressant versus placebo followed by antidepressant in reducing psychotic symptoms in patients with a diagnosis of psychotic depression.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

Thaddeus Block, MD
Corcept Therapeutics
Study Director
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

42 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

K&s Professional Research Services, Llc
Little Rock, Arkansas, United States
Woodland International Research Group, Inc.
Little Rock, Arkansas, United States
South Coast Clinical Trials, Inc
Anaheim, California, United States
Diligent Clinical Trials
Downey, California, United States
Synergy Clinical Research Center
Escondido, California, United States
Collaborative Neuroscience Network, Inc.
Garden Grove, California, United States
Pacific Research Partners
Oakland, California, United States
North County Clinical Research
Oceanside, California, United States
Breakthrough Clinical Trials
San Bernardino, California, United States
Cnri, Llc
San Diego, California, United States
Sharp Mesa Vista Hospital
San Diego, California, United States
Professional Clinical Research, Inc.
Aventura, Florida, United States
University of Florida
Gainesville, Florida, United States
Segal Institute for Clinical Research
Hollywood, Florida, United States
Accurate Clinical Trials
Kissimmee, Florida, United States
Amb Research Center
Miami, Florida, United States
Lakeside Behavioral Health
Orlando, Florida, United States
University of South Florida Dept of Psychiatry and Neurosciences
Tampa, Florida, United States
Atlanta Center for Medical Research
Atlanta, Georgia, United States
Alexian Brothers Center for Psychiatric Research
Hoffman Estates, Illinois, United States
Precise Research Centers
Flowood, Mississippi, United States
Millennium Psychiatric Associate
Creve Coeur, Missouri, United States
Psychcare Consultants Research
St Louis, Missouri, United States
Cri Lifetree
Marlton, New Jersey, United States
Neurobehavioral Research, Inc.
Cedarhurst, New York, United States
the Zucker Hillside Hospital
Glen Oaks, New York, United States
Inquest Clinical Group/ Global Research Associates
Hope Mills, North Carolina, United States
Wake Forest University Baptist Medical Center
Winston-Salem, North Carolina, United States
Midwest Clinical Research Center
Dayton, Ohio, United States
Oklahoma Clinical Research Center
Oklahoma City, Oklahoma, United States
Lehigh Center for Clinical Research
Allentown, Pennsylvania, United States
Belmont Center for Comprehensive Treatment
Philadelphia, Pennsylvania, United States
University of Pittsburgh Medical Center (upmc)
Pittsburgh, Pennsylvania, United States
Carolina Clinical Trials, Inc.
Charleston, South Carolina, United States
Futuresearch Clinical Trials, L.P.
Austin, Texas, United States
Pillar Clinical Research, Llc
Dallas, Texas, United States
University of Texas Southwestern Medical Center
Dallas, Texas, United States
Insite Clinical Research, Llc
DeSoto, Texas, United States
Claghorn-Lesem Research Clinic
Houston, Texas, United States
Clinical Trial Network
Houston, Texas, United States

2 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Mifepristone →Placebo

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 31 Mar 2008
Primary completion: 30 Jun 2014
Completion: 30 Jun 2014
Last update posted: 5 Jun 2017
Registered enrollment: 292
Registry id: NCT00637494

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.