Clinical trialNCT00653068CompletedPhase 3Interventional

Combination Chemotherapy, Radiation Therapy, and an Autologous Peripheral Blood Stem Cell Transplant in Treating Young Patients With Atypical Teratoid/Rhabdoid Tumor of the Central Nervous System

SponsorChildren's Oncology GroupEnrollment70Childhood Atypical Teratoid/Rhabdoid Tumor

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This phase III trial studies the side effects of combination chemotherapy, 3-dimensional conformal radiation therapy, and an autologous peripheral blood stem cell transplant, and to see how well they work in treating young patients with atypical teratoid/rhabdoid tumor of the central nervous system. Giving high-dose chemotherapy before an autologous peripheral blood stem cell transplant stops the growth of cancer cells by stopping them from dividing or killing them. Giving colony-stimulating factors, such as G-CSF, helps stem cells move from the bone marrow to the blood so they can be collected and stored. Chemotherapy or radiation therapy is then given to prepare the bone marrow for the stem cell transplant. The stem cells are then returned to the patient to replace the blood-forming cells that were destroyed by the chemotherapy or radiation therapy.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

Alyssa T Reddy
Children's Oncology Group
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

94 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Australia

Royal Children'S Hospital
Parkville, Victoria, Australia
Princess Margaret Hospital for Children
Perth, Western Australia, Australia

Canada

Alberta Children'S Hospital
Calgary, Alberta, Canada
Mcmaster Children'S Hospital at Hamilton Health Sciences
Hamilton, Ontario, Canada
Kingston Health Sciences Centre
Kingston, Ontario, Canada
Hospital for Sick Children
Toronto, Ontario, Canada
Centre Hospitalier Universitaire Sainte-Justine
Montreal, Quebec, Canada

United States

Children'S Hospital of Alabama
Birmingham, Alabama, United States
University of Alabama at Birmingham Cancer Center
Birmingham, Alabama, United States
University of Arkansas for Medical Sciences
Little Rock, Arkansas, United States
Kaiser Permanente Downey Medical Center
Downey, California, United States
Miller Children'S and Women'S Hospital Long Beach
Long Beach, California, United States
Children'S Hospital Los Angeles
Los Angeles, California, United States
Valley Children'S Hospital
Madera, California, United States
Ucsf Benioff Children'S Hospital Oakland
Oakland, California, United States
Children'S Hospital of Orange County
Orange, California, United States
Rady Children'S Hospital - San Diego
San Diego, California, United States
Ucsf Medical Center-Mission Bay
San Francisco, California, United States
Ucsf Medical Center-Parnassus
San Francisco, California, United States
Connecticut Children'S Medical Center
Hartford, Connecticut, United States
Alfred I Dupont Hospital for Children
Wilmington, Delaware, United States
Children'S National Medical Center
Washington D.C., District of Columbia, United States
Golisano Children'S Hospital of Southwest Florida
Fort Myers, Florida, United States
Lee Memorial Health System
Fort Myers, Florida, United States
University of Florida Health Science Center - Gainesville
Gainesville, Florida, United States
Nemours Children'S Clinic-Jacksonville
Jacksonville, Florida, United States
University of Miami Miller School of Medicine-Sylvester Cancer Center
Miami, Florida, United States
Adventhealth Orlando
Orlando, Florida, United States
Nemours Children'S Clinic - Orlando
Orlando, Florida, United States
Orlando Health Cancer Institute
Orlando, Florida, United States
Nemours Children'S Clinic - Pensacola
Pensacola, Florida, United States
Johns Hopkins All Children'S Hospital
St. Petersburg, Florida, United States
Saint Joseph'S Hospital/children'S Hospital-Tampa
Tampa, Florida, United States
Saint Mary'S Hospital
West Palm Beach, Florida, United States
Children'S Healthcare of Atlanta - Egleston
Atlanta, Georgia, United States
University of Hawaii Cancer Center
Honolulu, Hawaii, United States
Lurie Children'S Hospital-Chicago
Chicago, Illinois, United States
University of Chicago Comprehensive Cancer Center
Chicago, Illinois, United States
Loyola University Medical Center
Maywood, Illinois, United States
Riley Hospital for Children
Indianapolis, Indiana, United States

54 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Carboplatin →Cisplatin →Cyclophosphamide →Etoposide →Filgrastim →Leucovorin →Methotrexate →ThiotepaVincristine →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 10 Feb 2009
Primary completion: 27 Sept 2016
Completion: 31 Mar 2024
Last update posted: 23 Apr 2024
Registered enrollment: 70
Registry id: NCT00653068

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 4 Nov 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.