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Clinical trialNCT00671034CompletedPhase 3Interventional

Calaspargase Pegol or Pegaspargase and Combination Chemotherapy in Treating Younger Patients With Newly Diagnosed High-Risk Acute Lymphoblastic Leukemia

SponsorChildren's Oncology GroupEnrollment166Acute Lymphoblastic LeukemiaAdult B Acute Lymphoblastic LeukemiaChildhood B Acute Lymphoblastic Leukemia
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This randomized clinical trial is studying giving calaspargase pegol together with combination chemotherapy to see how well it works compared with giving pegaspargase together with combination chemotherapy in treating younger patients with newly diagnosed high-risk acute lymphoblastic leukemia. Drugs used in chemotherapy work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) may kill more cancer cells.

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

27 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States
  • University of Alabama at Birmingham Cancer Center

    Birmingham, Alabama, United States

  • Children'S Hospital of Orange County

    Orange, California, United States

  • Lucile Packard Children'S Hospital Stanford University

    Palo Alto, California, United States

  • Children'S Hospital Colorado

    Aurora, Colorado, United States

  • University of Connecticut

    Farmington, Connecticut, United States

  • Connecticut Children'S Medical Center

    Hartford, Connecticut, United States

  • Children'S National Medical Center

    Washington D.C., District of Columbia, United States

  • Lurie Children'S Hospital-Chicago

    Chicago, Illinois, United States

  • Indiana University/melvin and Bren Simon Cancer Center

    Indianapolis, Indiana, United States

  • Riley Hospital for Children

    Indianapolis, Indiana, United States

  • Johns Hopkins University/sidney Kimmel Cancer Center

    Baltimore, Maryland, United States

  • Wayne State University/karmanos Cancer Institute

    Detroit, Michigan, United States

  • Children'S Hospitals and Clinics of Minnesota - Minneapolis

    Minneapolis, Minnesota, United States

  • University of Minnesota/masonic Cancer Center

    Minneapolis, Minnesota, United States

  • Washington University School of Medicine

    St Louis, Missouri, United States

  • Hackensack University Medical Center

    Hackensack, New Jersey, United States

  • University of New Mexico Cancer Center

    Albuquerque, New Mexico, United States

  • Laura and Isaac Perlmutter Cancer Center at Nyu Langone

    New York, New York, United States

  • Cincinnati Children'S Hospital Medical Center

    Cincinnati, Ohio, United States

  • University of Oklahoma Health Sciences Center

    Oklahoma City, Oklahoma, United States

  • Oregon Health and Science University

    Portland, Oregon, United States

  • Children'S Hospital of Philadelphia

    Philadelphia, Pennsylvania, United States

  • Children'S Hospital of Pittsburgh of Upmc

    Pittsburgh, Pennsylvania, United States

  • Vanderbilt University/ingram Cancer Center

    Nashville, Tennessee, United States

  • Ut Southwestern/simmons Cancer Center-Dallas

    Dallas, Texas, United States

  • Primary Children'S Hospital

    Salt Lake City, Utah, United States

  • Seattle Children'S Hospital

    Seattle, Washington, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
21 Jul 2008
Primary completion
1 Feb 2011
Completion
31 Mar 2021
Last update posted
27 Apr 2021
Registered enrollment
166
Registry id
NCT00671034

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.