Clinical trialNCT00675584CompletedPhase 3Interventional

CARE Network Maintenance Versus Intermittent Inhaled Steroids in Wheezing Toddlers (MIST)

SponsorMilton S. Hershey Medical CenterEnrollment278Asthma

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

Asthma affects about 4 million children in the United States and is a leading cause of hospitalizations and school absenteeism. Continuous wheezing in very young children may develop into asthma. Low doses of inhaled corticosteroids (ICS) are commonly prescribed to treat children with particularly bad wheezing episodes. This study will compare the safety and effectiveness of low doses of ICS taken daily versus higher doses of ICS taken only during respiratory tract illnesses for toddlers with continuous wheezing or coughing illnesses.

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Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

David T. Mauger, PhD
Penn State College of Medicine
Principal Investigator
clinicaltrials.gov ↗
Fernando D. Martinez, MD
University of Arizona College of Medicine
Principal InvestigatorKOL profile →
clinicaltrials.gov ↗
Lynn M. Taussig, MD
University of Denver
Study Chair
clinicaltrials.gov ↗
Robert C. Strunk, MD
Washington University School of Medicine
Principal Investigator
clinicaltrials.gov ↗
Robert F. Lemanske, Jr., MD
University of Wisconsin, Madison
Principal Investigator
clinicaltrials.gov ↗
Robert S. Zeiger, MD, PhD
Kaiser Permanente Medical Center
Principal Investigator
clinicaltrials.gov ↗
Stanley J. Szefler, MD, PhD
National Jewish Health
Principal InvestigatorKOL profile →
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

5 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

University of Arizona College of Medicine
Tucson, Arizona, United States
Kaiser Permanente Medical Center
San Diego, California, United States
National Jewish Medical and Research Center
Denver, Colorado, United States
Washington University School of Medicine
St Louis, Missouri, United States
University of Wisconsin - Madison
Madison, Wisconsin, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Budesonide →Placebo Budesonide

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 31 Aug 2008
Primary completion: 31 Jul 2010
Completion: 31 Jul 2010
Last update posted: 26 Jun 2018
Registered enrollment: 278
Registry id: NCT00675584

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.