Clinical trialNCT00705341CompletedPhase 4Interventional

MethaCholine Bronchoprovocation Study (MeCIS)

SponsorJohns Hopkins Bloomberg School of Public HealthEnrollment219Asthma

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The purpose of this research is to evaluate the methacholine challenge test as an accurate indicator of asthma in patients receiving treatment for asthma. Phase 1 on the study compares methacholine challenge test results from asthma patients to those from people who do not have asthma. In phase 2, test results for people with asthma on low dose inhaled corticosteroid will be compared to results on high dose inhaled corticosteroids. Both males and females with stable asthma (asthma participants) and without asthma (controls) enrolled. Participants will be between 12 and 69 years of age.

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Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Kaharu Sumino, MD
St. Louis Asthma Clinical Research Center
Principal Investigator
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A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

13 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

University of California at San Diego
San Diego, California, United States
the Nemours Children'S Clinic
Jacksonville, Florida, United States
University of Miami/univestiy of South Florida
Miami, Florida, United States
Northwestern University Memorial Hospital
Chicago, Illinois, United States
Indiana University
Indianapolis, Indiana, United States
Louisianna State University
New Orleans, Louisiana, United States
University of Missouri-Kansas City
Kansas City, Missouri, United States
Washington University School of Medicine
St Louis, Missouri, United States
Long Island Jewish Medical Center
New Hyde Park, New York, United States
New York Consortium/columbia University
New York, New York, United States
New York Medical College
Valhalla, New York, United States
Ohio State University
Columbus, Ohio, United States
Vermont Lung Center at the University of Vermont
Burlington, Vermont, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Fluticasone →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 31 Jan 2009
Primary completion: 28 Feb 2010
Completion: 28 Feb 2010
Last update posted: 12 Feb 2013
Registered enrollment: 219
Registry id: NCT00705341

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.