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Clinical trialNCT00709371CompletedPhase 2Interventional

Zonisamide SR Plus Bupropion SR Combination Therapy in Subjects With Obesity

SponsorOrexigen Therapeutics, IncEnrollment729Obesity
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The purpose of this study is determine if the combination of zonisamide SR and bupropion SR are is more effective than either drug given alone or placebo in the treatment of obesity.

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

20 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States
  • Selfcenter, Pc

    Fairhope, Alabama, United States

  • Nutrition and Metabolic Research

    La Jolla, California, United States

  • Center for Human Nutrition/ucd

    Denver, Colorado, United States

  • Miami Research Associates

    Miami, Florida, United States

  • Csra Partners in Health, Inc.

    Augusta, Georgia, United States

  • Radiant Research, Chicago

    Chicago, Illinois, United States

  • Welborn Clinic

    Evansville, Indiana, United States

  • Pennington Biomedical Research Center

    Baton Rouge, Louisiana, United States

  • Nutrition and Weight Management Center, Boston Medical Center

    Boston, Massachusetts, United States

  • Futurecare Studies

    Springfield, Massachusetts, United States

  • Summit Research Network (michigan), Inc.

    Farmington Hills, Michigan, United States

  • Mercy Health Research

    St Louis, Missouri, United States

  • Center for Nutrition and Metabolic Disorders, University of Nevada School of Medicine

    Reno, Nevada, United States

  • Behavioral Medical Research

    Staten Island, New York, United States

  • Internal Medicine Associates of Charlotte

    Charlotte, North Carolina, United States

  • Wake Research Associates, Llc

    Raleigh, North Carolina, United States

  • Summit Research Network (oregon), Inc.

    Portland, Oregon, United States

  • the Cooper Institute

    Dallas, Texas, United States

  • Washington Center for Weight Management and Research

    Arlington, Virginia, United States

  • Summit Research Network (seattle), Llc.

    Seattle, Washington, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Zonisamide SR 120 mg/day/ bupropion SR 360 mg/dayZonisamide SR 120 mg/day/ bupropion SR placeboZonisamide SR 360 mg/day/ bupropion SR 360 mg/dayZonisamide SR 360 mg/day/ bupropion SR placeboZonisamide SR placebo/ bupropion SR 360 mg/dayZonisamide SR placebo/ bupropion SR placebo
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
31 Jul 2008
Primary completion
30 Apr 2009
Completion
31 Jul 2009
Last update posted
29 Nov 2012
Registered enrollment
729
Registry id
NCT00709371

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.