Clinical trialNCT00712426TerminatedPhase 3Interventional

Creatine Safety, Tolerability, & Efficacy in Huntington's Disease (CREST-E)

SponsorMassachusetts General HospitalEnrollment553Huntington's Disease

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

Huntington's disease (HD) is a slowly progressive disorder that devastates the lives of those affected and their families. There are no treatments that slow the progression of HD, only mildly effective symptomatic therapies are available.Creatine monohydrate is considered a nutritional supplement. The purpose of CREST-E is to test whether high-dose creatine can slow the progressive functional decline that occurs in persons 18 years or older with early clinical features of HD. The long-term safety, tolerability and effectiveness of up to 40 grams daily creatine compared to placebo is studied. A variety of biological processes are assessed for markers of disease activity or progression and creatine effects. Up to 50 active research centers globally will enroll 650 subjects.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Diana Rosas, MD, MS
Massachusetts General Hospital
Principal Investigator
clinicaltrials.gov ↗
Giovanni Schifitto, MD
University of Rochester Clinical Trial Coordination Center
Principal Investigator
clinicaltrials.gov ↗
Steven M Hersch, MD, PhD
Massachusetts General Hospital
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

47 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Australia

Westmead Hospital
Wentworthville, New South Wales, Australia
Neurodegenerative Disorders Research
Subiaco, Western Australia, Australia

Canada

University of Alberta
Edmonton, Alberta, Canada
University of Alberta Hospital
Edmonton, Alberta, Canada
Movement Disorder Clinic Deer Lodge Center
Winnipeg, Manitoba, Canada
Chum - Hopital Notre-Dame
Montreal, Quebec, Canada
University of Quebec Infant-Jesus Hospital (centre Hospitalier Affilie)
Québec, Quebec, Canada

New Zealand

Auckland City Hospital
Auckland, New Zealand
New Zealand Brain Research Institute
Christchurch, New Zealand

United States

University of Alabama
Birmingham, Alabama, United States
University of California, Irvine
Irvine, California, United States
University of California Davis
Sacramento, California, United States
University of Connecticut
Farmington, Connecticut, United States
University of Florida (mcknight Brain Institute)
Gainesville, Florida, United States
University of South Florida
Tampa, Florida, United States
Emory University School of Medicine
Atlanta, Georgia, United States
Georgia Regents University
Augusta, Georgia, United States
Rush University Medical Center
Chicago, Illinois, United States
Indiana University
Indianapolis, Indiana, United States
University of Iowa
Iowa City, Iowa, United States
University of Kansas Medical Center
Kansas City, Kansas, United States
Hereditary Neurological Disease Center (hndc)
Wichita, Kansas, United States
University of Louisville
Louisville, Kentucky, United States
University of Maryland School of Medicine
Baltimore, Maryland, United States
Massachusetts General Hospital
Boston, Massachusetts, United States
University of Michigan
Ann Arbor, Michigan, United States
Struthers Parkinson'S Center
Golden Valley, Minnesota, United States
Washington University School of Medicine
St Louis, Missouri, United States
Nebraska Medical Center
Omaha, Nebraska, United States
Cooper University Hospital
Camden, New Jersey, United States
Albany Medical College
Albany, New York, United States
North Shore-Lij Health System
Manhasset, New York, United States
Columbia University Medical Center
New York, New York, United States
University of Rochester
Rochester, New York, United States
Duke University
Durham, North Carolina, United States
Wake Forest University School of Medicine
Winston-Salem, North Carolina, United States
University of Cincinnati
Cincinnati, Ohio, United States
Cleveland Clinic
Cleveland, Ohio, United States
Ohio State University
Columbus, Ohio, United States
University of Pennsylvania
Philadelphia, Pennsylvania, United States

7 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

CreatinePlacebo

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 30 Sept 2009
Primary completion: 31 Dec 2014
Completion: 31 Jan 2015
Last update posted: 11 Mar 2016
Registered enrollment: 553
Registry id: NCT00712426

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.