Clinical trialNCT00730171CompletedPhase 3Interventional

An Open-label, Long-term Safety Study of Linaclotide in Patients With Chronic Constipation or Irritable Bowel Syndrome With Constipation

SponsorIronwood Pharmaceuticals, Inc.Enrollment1,743Chronic ConstipationIrritable Bowel Syndrome With Constipation

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The objective of this study is to assess the long-term safety of linaclotide administered to patients with chronic constipation (CC) or irritable bowel syndrome with constipation (IBS-C).

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Jeffrey M. Johnston, MD, FACP
Ironwood Pharmaceuticals, Inc.
Study Chair
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

116 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Ironwood Investigational Site
Birmingham, Alabama, United States
Ironwood Investigational Site
Huntsville, Alabama, United States
Ironwood Investigational Site
Chandler, Arizona, United States
Ironwood Investigational Site
Phoenix, Arizona, United States
Ironwood Investigational Site
Tucson, Arizona, United States
Ironwood Investigational Site
Tucson, Arizona, United States
Ironwood Investigational Site
Tucson, Arizona, United States
Ironwood Investigational Site
Sherwood, Arkansas, United States
Ironwood Investigational Site
Anaheim, California, United States
Ironwood Investigational Site
Chula Vista, California, United States
Ironwood Investigational Site
Encinitas, California, United States
Ironwood Investigational Site
Garden Grove, California, United States
Ironwood Investigational Site
Laguna Hills, California, United States
Ironwood Investigational Site
Los Angeles, California, United States
Ironwood Investigational Site
Orange, California, United States
Ironwood Investigational Site
Sacramento, California, United States
Ironwood Investigational Site
San Carlos, California, United States
Ironwood Investigational Site
San Diego, California, United States
Ironwood Investigational Site
San Diego, California, United States
Ironwood Investigational Site
San Diego, California, United States
Ironwood Investigational Site
Colorado Springs, Colorado, United States
Ironwood Investigational Site
Bristol, Connecticut, United States
Ironwood Investigational Site
Boynton Beach, Florida, United States
Ironwood Investigational Site
Hollywood, Florida, United States
Ironwood Investigational Site
Inverness, Florida, United States
Ironwood Investigational Site
Jacksonville, Florida, United States
Ironwood Investigational Site
Jacksonville, Florida, United States
Ironwood Investigational Site
Lauderdale Lakes, Florida, United States
Ironwood Investigational Site
Miami, Florida, United States
Ironwood Investigational Site
Pinellas Park, Florida, United States
Ironwood Investigational Site
Port Orange, Florida, United States
Ironwood Investigational Site
Tampa, Florida, United States
Ironwood Investigational Site
Newnan, Georgia, United States
Ironwood Investigational Site
Peoria, Illinois, United States
Ironwood Investigational Site
Anderson, Indiana, United States
Ironwood Investigational Site
Clive, Iowa, United States
Ironwood Investigational Site
Davenport, Iowa, United States
Ironwood Investigational Site
Mission, Kansas, United States
Ironwood Investigational Site
Overland Park, Kansas, United States
Ironwood Investigational Site
Topeka, Kansas, United States

76 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Linaclotide →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 30 Sept 2008
Primary completion: 31 Mar 2012
Completion: 31 Mar 2012
Last update posted: 19 Feb 2018
Registered enrollment: 1,743
Registry id: NCT00730171

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.